Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism

•ACSL4 is involved in arachidonic acid incorporation into phospholipids.•ACSL4 maintains the levels of phospholipids bearing PUFAs.•ACSL4 participates in the progression of several cancers.•ACSL4 is involved in PUFA-mediated cell death. The activation of long-chain free fatty acids is the first step...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2019-10, Vol.144, p.106363-106363, Article 106363
Hauptverfasser:	Kuwata, Hiroshi, Hara, Shuntaro
Format:	Artikel
Sprache:	eng
Schlagworte:	ACSL4 acyl-CoA synthetase Animals Arachidonic acid Arachidonic Acid - metabolism Brain - metabolism Cell Death Coenzyme A Ligases - metabolism Eicosanoid Humans Mitochondria - metabolism Phospholipids - metabolism Polyunsaturated fatty acid
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