CD4+ T cell signatures in HIV infection

Analysis of the whole-genome transcriptional activity of HIV-specific CD4 + T cells demonstrates distinct profiles associated with natural control of HIV replication, as well as dysfunctional phenotypes that persist even after effective antiretroviral therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2019-08, Vol.20 (8), p.948-950
Hauptverfasser:	Gubser, Celine, Pitman, Matthew C, Lewin, Sharon R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1898/1270 631/250/2499 631/250/255/1901 631/326/596/2558 Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biomedical and Life Sciences Biomedicine CD4 antigen Genomes HIV Human immunodeficiency virus Immunology Infectious Diseases Lymphocytes Lymphocytes T News & Views news-and-views Phenotypes Transcription
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Beschreibung
Zusammenfassung:	Analysis of the whole-genome transcriptional activity of HIV-specific CD4 + T cells demonstrates distinct profiles associated with natural control of HIV replication, as well as dysfunctional phenotypes that persist even after effective antiretroviral therapy.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-019-0447-5