2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial
For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to investigate the short-term and long-term effects of calorie restriction with adequate nutrition on these risk factors in health...
Gespeichert in:
| Veröffentlicht in: | The lancet. Diabetes & endocrinology 2019-09, Vol.7 (9), p.673-683 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 683 |
|---|---|
| container_issue | 9 |
| container_start_page | 673 |
| container_title | The lancet. Diabetes & endocrinology |
| container_volume | 7 |
| creator | Kraus, William E Bhapkar, Manjushri Huffman, Kim M Pieper, Carl F Krupa Das, Sai Redman, Leanne M Villareal, Dennis T Rochon, James Roberts, Susan B Ravussin, Eric Holloszy, John O Fontana, Luigi |
| description | For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to investigate the short-term and long-term effects of calorie restriction with adequate nutrition on these risk factors in healthy, lean, or slightly overweight young and middle-aged individuals.
CALERIE was a phase 2, multicentre, randomised controlled trial in young and middle-aged (21–50 years), healthy non-obese (BMI 22·0–27·9 kg/m2) men and women done in three clinical centres in the USA. Participants were randomly assigned (2:1) to a 25% calorie restriction diet or an ad libitum control diet. Exploratory cardiometabolic risk factor responses to a prescribed 25% calorie restriction diet for 2 years were evaluated (systolic, diastolic, and mean blood pressure; plasma lipids; high-sensitivity C-reactive protein; metabolic syndrome score; and glucose homoeostasis measures of fasting insulin, glucose, insulin resistance, and 2-h glucose, area-under-the curve for glucose, and insulin from an oral glucose tolerance test) analysed in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00427193.
From May 8, 2007, to Feb 26, 2010, of 238 participants that were assessed, 218 were randomly assigned to and started a 25% calorie restriction diet (n=143, 66%) or an ad libitum control diet (n=75, 34%). Individuals in the calorie restriction group achieved a mean reduction in calorie intake of 11·9% (SE 0·7; from 2467 kcal to 2170 kcal) versus 0·8% (1·0) in the control group, and a sustained mean weight reduction of 7·5 kg (SE 0·4) versus an increase of 0·1 kg (0·5) in the control group, of which 71% (mean change in fat mass 5·3 kg [SE 0·3] divided by mean change in weight 7·5 kg [0·4]) was fat mass loss. Calorie restriction caused a persistent and significant reduction from baseline to 2 years of all measured conventional cardiometabolic risk factors, including change scores for LDL-cholesterol (p |
| doi_str_mv | 10.1016/S2213-8587(19)30151-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2258152577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2213858719301512</els_id><sourcerecordid>2258152577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-81dd1d73d5fcbbd263b6709280339f38341c210f4864bf8e95d2d0d7158c8a2d3</originalsourceid><addsrcrecordid>eNqFUctuFDEQtBCIRCGfAPJxI2XAba9nPFwQipYkUiQkHmfLY_cIg2e82B7E_gTfjPdBrpzcaldXdXUR8hLYa2DQvvnMOYhGSdWtoL8SDCQ0_Ak5P7V7-fSxVt0Zucz5O2MMmBStYs_JmQDBhOjZOfnD6Q5NyjSO1JoQk0eaMJfkbfFxpmZ2tZ-cjxMWM8TgLU0-_6Crm_cPm0_3m6u3FH9v66ApMe1oXIqt0AOfodMSirc4l4TXdPvNZKT8mqZKGiefsVLH-hdDqGWVNOEFeTaakPHy9F6Qrx82X27umoePt_dVsbFr4KVR4By4Tjg52mFwvBVD27Geq72rUSixBsuBjWvVrodRYS8dd8x1IJVVhjtxQVZH3m2KP5fqV9d9LIZgZoxL1pxLBZLLrqtQeYTaFHNOOOpt8pNJOw1M79PQhzT0_tQaen1IQ_M69-oksQwTusepf7evgHdHAFajvzwmna3H2aLzCW3RLvr_SPwFhAGZ8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2258152577</pqid></control><display><type>article</type><title>2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kraus, William E ; Bhapkar, Manjushri ; Huffman, Kim M ; Pieper, Carl F ; Krupa Das, Sai ; Redman, Leanne M ; Villareal, Dennis T ; Rochon, James ; Roberts, Susan B ; Ravussin, Eric ; Holloszy, John O ; Fontana, Luigi</creator><creatorcontrib>Kraus, William E ; Bhapkar, Manjushri ; Huffman, Kim M ; Pieper, Carl F ; Krupa Das, Sai ; Redman, Leanne M ; Villareal, Dennis T ; Rochon, James ; Roberts, Susan B ; Ravussin, Eric ; Holloszy, John O ; Fontana, Luigi ; CALERIE Investigators</creatorcontrib><description><![CDATA[For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to investigate the short-term and long-term effects of calorie restriction with adequate nutrition on these risk factors in healthy, lean, or slightly overweight young and middle-aged individuals.
CALERIE was a phase 2, multicentre, randomised controlled trial in young and middle-aged (21–50 years), healthy non-obese (BMI 22·0–27·9 kg/m2) men and women done in three clinical centres in the USA. Participants were randomly assigned (2:1) to a 25% calorie restriction diet or an ad libitum control diet. Exploratory cardiometabolic risk factor responses to a prescribed 25% calorie restriction diet for 2 years were evaluated (systolic, diastolic, and mean blood pressure; plasma lipids; high-sensitivity C-reactive protein; metabolic syndrome score; and glucose homoeostasis measures of fasting insulin, glucose, insulin resistance, and 2-h glucose, area-under-the curve for glucose, and insulin from an oral glucose tolerance test) analysed in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00427193.
From May 8, 2007, to Feb 26, 2010, of 238 participants that were assessed, 218 were randomly assigned to and started a 25% calorie restriction diet (n=143, 66%) or an ad libitum control diet (n=75, 34%). Individuals in the calorie restriction group achieved a mean reduction in calorie intake of 11·9% (SE 0·7; from 2467 kcal to 2170 kcal) versus 0·8% (1·0) in the control group, and a sustained mean weight reduction of 7·5 kg (SE 0·4) versus an increase of 0·1 kg (0·5) in the control group, of which 71% (mean change in fat mass 5·3 kg [SE 0·3] divided by mean change in weight 7·5 kg [0·4]) was fat mass loss. Calorie restriction caused a persistent and significant reduction from baseline to 2 years of all measured conventional cardiometabolic risk factors, including change scores for LDL-cholesterol (p<0·0001), total cholesterol to HDL-cholesterol ratio (p<0·0001), and systolic (p<0·0011) and diastolic (p<0·0001) blood pressure. In addition, calorie restriction resulted in a significant improvement at 2 years in C-reactive protein (p=0·012), insulin sensitivity index (p<0·0001), and metabolic syndrome score (p<0·0001) relative to control. A sensitivity analysis revealed the responses to be robust after controlling for relative weight loss changes.
2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. These findings suggest the potential for a substantial advantage for cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits.
National Institute on Aging and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.]]></description><identifier>ISSN: 2213-8587</identifier><identifier>EISSN: 2213-8595</identifier><identifier>DOI: 10.1016/S2213-8587(19)30151-2</identifier><identifier>PMID: 31303390</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Blood Pressure ; Caloric Restriction ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diet therapy ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - prevention & control ; Cholesterol, LDL - blood ; Female ; Glucose Tolerance Test ; Humans ; Male ; Metabolic Diseases - blood ; Metabolic Diseases - diet therapy ; Metabolic Diseases - physiopathology ; Metabolic Diseases - prevention & control ; Middle Aged ; Overweight - blood ; Overweight - complications ; Overweight - physiopathology ; Overweight - prevention & control ; Prospective Studies ; Time Factors ; Treatment Outcome ; Weight Loss ; Young Adult</subject><ispartof>The lancet. Diabetes & endocrinology, 2019-09, Vol.7 (9), p.673-683</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-81dd1d73d5fcbbd263b6709280339f38341c210f4864bf8e95d2d0d7158c8a2d3</citedby><cites>FETCH-LOGICAL-c412t-81dd1d73d5fcbbd263b6709280339f38341c210f4864bf8e95d2d0d7158c8a2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31303390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraus, William E</creatorcontrib><creatorcontrib>Bhapkar, Manjushri</creatorcontrib><creatorcontrib>Huffman, Kim M</creatorcontrib><creatorcontrib>Pieper, Carl F</creatorcontrib><creatorcontrib>Krupa Das, Sai</creatorcontrib><creatorcontrib>Redman, Leanne M</creatorcontrib><creatorcontrib>Villareal, Dennis T</creatorcontrib><creatorcontrib>Rochon, James</creatorcontrib><creatorcontrib>Roberts, Susan B</creatorcontrib><creatorcontrib>Ravussin, Eric</creatorcontrib><creatorcontrib>Holloszy, John O</creatorcontrib><creatorcontrib>Fontana, Luigi</creatorcontrib><creatorcontrib>CALERIE Investigators</creatorcontrib><title>2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial</title><title>The lancet. Diabetes & endocrinology</title><addtitle>Lancet Diabetes Endocrinol</addtitle><description><![CDATA[For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to investigate the short-term and long-term effects of calorie restriction with adequate nutrition on these risk factors in healthy, lean, or slightly overweight young and middle-aged individuals.
CALERIE was a phase 2, multicentre, randomised controlled trial in young and middle-aged (21–50 years), healthy non-obese (BMI 22·0–27·9 kg/m2) men and women done in three clinical centres in the USA. Participants were randomly assigned (2:1) to a 25% calorie restriction diet or an ad libitum control diet. Exploratory cardiometabolic risk factor responses to a prescribed 25% calorie restriction diet for 2 years were evaluated (systolic, diastolic, and mean blood pressure; plasma lipids; high-sensitivity C-reactive protein; metabolic syndrome score; and glucose homoeostasis measures of fasting insulin, glucose, insulin resistance, and 2-h glucose, area-under-the curve for glucose, and insulin from an oral glucose tolerance test) analysed in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00427193.
From May 8, 2007, to Feb 26, 2010, of 238 participants that were assessed, 218 were randomly assigned to and started a 25% calorie restriction diet (n=143, 66%) or an ad libitum control diet (n=75, 34%). Individuals in the calorie restriction group achieved a mean reduction in calorie intake of 11·9% (SE 0·7; from 2467 kcal to 2170 kcal) versus 0·8% (1·0) in the control group, and a sustained mean weight reduction of 7·5 kg (SE 0·4) versus an increase of 0·1 kg (0·5) in the control group, of which 71% (mean change in fat mass 5·3 kg [SE 0·3] divided by mean change in weight 7·5 kg [0·4]) was fat mass loss. Calorie restriction caused a persistent and significant reduction from baseline to 2 years of all measured conventional cardiometabolic risk factors, including change scores for LDL-cholesterol (p<0·0001), total cholesterol to HDL-cholesterol ratio (p<0·0001), and systolic (p<0·0011) and diastolic (p<0·0001) blood pressure. In addition, calorie restriction resulted in a significant improvement at 2 years in C-reactive protein (p=0·012), insulin sensitivity index (p<0·0001), and metabolic syndrome score (p<0·0001) relative to control. A sensitivity analysis revealed the responses to be robust after controlling for relative weight loss changes.
2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. These findings suggest the potential for a substantial advantage for cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits.
National Institute on Aging and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.]]></description><subject>Adult</subject><subject>Blood Pressure</subject><subject>Caloric Restriction</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diet therapy</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cholesterol, LDL - blood</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Diseases - blood</subject><subject>Metabolic Diseases - diet therapy</subject><subject>Metabolic Diseases - physiopathology</subject><subject>Metabolic Diseases - prevention & control</subject><subject>Middle Aged</subject><subject>Overweight - blood</subject><subject>Overweight - complications</subject><subject>Overweight - physiopathology</subject><subject>Overweight - prevention & control</subject><subject>Prospective Studies</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Weight Loss</subject><subject>Young Adult</subject><issn>2213-8587</issn><issn>2213-8595</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctuFDEQtBCIRCGfAPJxI2XAba9nPFwQipYkUiQkHmfLY_cIg2e82B7E_gTfjPdBrpzcaldXdXUR8hLYa2DQvvnMOYhGSdWtoL8SDCQ0_Ak5P7V7-fSxVt0Zucz5O2MMmBStYs_JmQDBhOjZOfnD6Q5NyjSO1JoQk0eaMJfkbfFxpmZ2tZ-cjxMWM8TgLU0-_6Crm_cPm0_3m6u3FH9v66ApMe1oXIqt0AOfodMSirc4l4TXdPvNZKT8mqZKGiefsVLH-hdDqGWVNOEFeTaakPHy9F6Qrx82X27umoePt_dVsbFr4KVR4By4Tjg52mFwvBVD27Geq72rUSixBsuBjWvVrodRYS8dd8x1IJVVhjtxQVZH3m2KP5fqV9d9LIZgZoxL1pxLBZLLrqtQeYTaFHNOOOpt8pNJOw1M79PQhzT0_tQaen1IQ_M69-oksQwTusepf7evgHdHAFajvzwmna3H2aLzCW3RLvr_SPwFhAGZ8Q</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Kraus, William E</creator><creator>Bhapkar, Manjushri</creator><creator>Huffman, Kim M</creator><creator>Pieper, Carl F</creator><creator>Krupa Das, Sai</creator><creator>Redman, Leanne M</creator><creator>Villareal, Dennis T</creator><creator>Rochon, James</creator><creator>Roberts, Susan B</creator><creator>Ravussin, Eric</creator><creator>Holloszy, John O</creator><creator>Fontana, Luigi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201909</creationdate><title>2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial</title><author>Kraus, William E ; Bhapkar, Manjushri ; Huffman, Kim M ; Pieper, Carl F ; Krupa Das, Sai ; Redman, Leanne M ; Villareal, Dennis T ; Rochon, James ; Roberts, Susan B ; Ravussin, Eric ; Holloszy, John O ; Fontana, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-81dd1d73d5fcbbd263b6709280339f38341c210f4864bf8e95d2d0d7158c8a2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Blood Pressure</topic><topic>Caloric Restriction</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diet therapy</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Cholesterol, LDL - blood</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Diseases - blood</topic><topic>Metabolic Diseases - diet therapy</topic><topic>Metabolic Diseases - physiopathology</topic><topic>Metabolic Diseases - prevention & control</topic><topic>Middle Aged</topic><topic>Overweight - blood</topic><topic>Overweight - complications</topic><topic>Overweight - physiopathology</topic><topic>Overweight - prevention & control</topic><topic>Prospective Studies</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Weight Loss</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraus, William E</creatorcontrib><creatorcontrib>Bhapkar, Manjushri</creatorcontrib><creatorcontrib>Huffman, Kim M</creatorcontrib><creatorcontrib>Pieper, Carl F</creatorcontrib><creatorcontrib>Krupa Das, Sai</creatorcontrib><creatorcontrib>Redman, Leanne M</creatorcontrib><creatorcontrib>Villareal, Dennis T</creatorcontrib><creatorcontrib>Rochon, James</creatorcontrib><creatorcontrib>Roberts, Susan B</creatorcontrib><creatorcontrib>Ravussin, Eric</creatorcontrib><creatorcontrib>Holloszy, John O</creatorcontrib><creatorcontrib>Fontana, Luigi</creatorcontrib><creatorcontrib>CALERIE Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The lancet. Diabetes & endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraus, William E</au><au>Bhapkar, Manjushri</au><au>Huffman, Kim M</au><au>Pieper, Carl F</au><au>Krupa Das, Sai</au><au>Redman, Leanne M</au><au>Villareal, Dennis T</au><au>Rochon, James</au><au>Roberts, Susan B</au><au>Ravussin, Eric</au><au>Holloszy, John O</au><au>Fontana, Luigi</au><aucorp>CALERIE Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial</atitle><jtitle>The lancet. Diabetes & endocrinology</jtitle><addtitle>Lancet Diabetes Endocrinol</addtitle><date>2019-09</date><risdate>2019</risdate><volume>7</volume><issue>9</issue><spage>673</spage><epage>683</epage><pages>673-683</pages><issn>2213-8587</issn><eissn>2213-8595</eissn><abstract><![CDATA[For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to investigate the short-term and long-term effects of calorie restriction with adequate nutrition on these risk factors in healthy, lean, or slightly overweight young and middle-aged individuals.
CALERIE was a phase 2, multicentre, randomised controlled trial in young and middle-aged (21–50 years), healthy non-obese (BMI 22·0–27·9 kg/m2) men and women done in three clinical centres in the USA. Participants were randomly assigned (2:1) to a 25% calorie restriction diet or an ad libitum control diet. Exploratory cardiometabolic risk factor responses to a prescribed 25% calorie restriction diet for 2 years were evaluated (systolic, diastolic, and mean blood pressure; plasma lipids; high-sensitivity C-reactive protein; metabolic syndrome score; and glucose homoeostasis measures of fasting insulin, glucose, insulin resistance, and 2-h glucose, area-under-the curve for glucose, and insulin from an oral glucose tolerance test) analysed in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00427193.
From May 8, 2007, to Feb 26, 2010, of 238 participants that were assessed, 218 were randomly assigned to and started a 25% calorie restriction diet (n=143, 66%) or an ad libitum control diet (n=75, 34%). Individuals in the calorie restriction group achieved a mean reduction in calorie intake of 11·9% (SE 0·7; from 2467 kcal to 2170 kcal) versus 0·8% (1·0) in the control group, and a sustained mean weight reduction of 7·5 kg (SE 0·4) versus an increase of 0·1 kg (0·5) in the control group, of which 71% (mean change in fat mass 5·3 kg [SE 0·3] divided by mean change in weight 7·5 kg [0·4]) was fat mass loss. Calorie restriction caused a persistent and significant reduction from baseline to 2 years of all measured conventional cardiometabolic risk factors, including change scores for LDL-cholesterol (p<0·0001), total cholesterol to HDL-cholesterol ratio (p<0·0001), and systolic (p<0·0011) and diastolic (p<0·0001) blood pressure. In addition, calorie restriction resulted in a significant improvement at 2 years in C-reactive protein (p=0·012), insulin sensitivity index (p<0·0001), and metabolic syndrome score (p<0·0001) relative to control. A sensitivity analysis revealed the responses to be robust after controlling for relative weight loss changes.
2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. These findings suggest the potential for a substantial advantage for cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits.
National Institute on Aging and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31303390</pmid><doi>10.1016/S2213-8587(19)30151-2</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2213-8587 |
| ispartof | The lancet. Diabetes & endocrinology, 2019-09, Vol.7 (9), p.673-683 |
| issn | 2213-8587 2213-8595 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2258152577 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Blood Pressure Caloric Restriction Cardiovascular Diseases - blood Cardiovascular Diseases - diet therapy Cardiovascular Diseases - physiopathology Cardiovascular Diseases - prevention & control Cholesterol, LDL - blood Female Glucose Tolerance Test Humans Male Metabolic Diseases - blood Metabolic Diseases - diet therapy Metabolic Diseases - physiopathology Metabolic Diseases - prevention & control Middle Aged Overweight - blood Overweight - complications Overweight - physiopathology Overweight - prevention & control Prospective Studies Time Factors Treatment Outcome Weight Loss Young Adult |
| title | 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T15%3A12%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=2%20years%20of%20calorie%20restriction%20and%20cardiometabolic%20risk%20(CALERIE):%20exploratory%20outcomes%20of%20a%20multicentre,%20phase%202,%20randomised%20controlled%20trial&rft.jtitle=The%20lancet.%20Diabetes%20&%20endocrinology&rft.au=Kraus,%20William%20E&rft.aucorp=CALERIE%20Investigators&rft.date=2019-09&rft.volume=7&rft.issue=9&rft.spage=673&rft.epage=683&rft.pages=673-683&rft.issn=2213-8587&rft.eissn=2213-8595&rft_id=info:doi/10.1016/S2213-8587(19)30151-2&rft_dat=%3Cproquest_cross%3E2258152577%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2258152577&rft_id=info:pmid/31303390&rft_els_id=S2213858719301512&rfr_iscdi=true |