Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance

Amorphous solid dispersions (ASDs) represent an important formulation technique to achieve supersaturation in gastrointestinal fluids and to enhance absorption of poorly water-soluble drugs. Drug release from such systems is complex due to emergence of different colloidal structures and potential dr...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2019-09, Vol.137, p.105001-105001, Article 105001
Hauptverfasser:	Jankovic, Sandra, O'Dwyer, Patrick J., Box, Karl J., Imanidis, Georgios, Reppas, Christos, Kuentz, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous drug Biphasic dissolution test Colloids Diffusing wave spectroscopy Drug Liberation Drug precipitation Ketoconazole - chemistry Methylcellulose - analogs & derivatives Methylcellulose - chemistry Microrheology Rheology Solid dispersion Spectrum Analysis - methods Suspensions
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