The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization

One hallmark of Alzheimer's disease (AD) is the presence of amyloid plaques, which mainly consist of the amyloid precursor protein (APP) cleavage product amyloid β (Aβ). For cleavage to occur, the APP must be endocytosed from the cell surface. The phosphatidylinositol binding clathrin assembly...

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Veröffentlicht in:	Biochemical journal 2019-07, Vol.476 (14), p.2093-2109
Hauptverfasser:	Merthan, Lisa, Haller, Amelie, Thal, Dietmar R, von Einem, Bjoern, von Arnim, Christine A F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amino Acid Motifs Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Endocytosis Female HEK293 Cells Humans Male Mice Middle Aged Monomeric Clathrin Assembly Proteins - genetics Monomeric Clathrin Assembly Proteins - metabolism Protein Domains
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