Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay

Type-1 ryanodine receptor (RyR1) is a calcium-release channel localized on sarcoplasmic reticulum (SR) of the skeletal muscle, and mediates muscle contraction by releasing Ca2+ from the SR. Genetic mutations of RyR1 are associated with skeletal muscle diseases such as malignant hyperthermia and cent...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-10, Vol.179, p.837-848
Hauptverfasser:	Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Ishigami-Yuasa, Mari, Murayama, Takashi, Nishijima, Yoshiaki, Sakurai, Akiko, Arai, Ryota, Kurebayashi, Nagomi, Sakurai, Takashi, Kagechika, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium ion channel Quinolone Ryanodine receptor
Online-Zugang:	Volltext
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