Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species‐induced apoptosis and reduces cell stemness

Thymoquinone is a phytochemical compound isolated from Nigella sativa and has various biological effects, including anti‐inflammation, antioxidation, and anticancer. Here, we further investigated the anticancer effects and associated molecular mechanism of 2‐methyl‐5‐isopropyl‐1,4‐benzoquinone (thym...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology 2019-11, Vol.34 (11), p.1208-1220
Hauptverfasser:	Liou, Yih‐Farng, Chen, Pei‐Ni, Chu, Shu‐Chen, Kao, Shao‐Hsuan, Chang, Yan‐Zin, Hsieh, Yih‐Shou, Chang, Horng‐Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Aldehyde dehydrogenase Aldehydes Animals Anticancer properties Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Benzoquinone Benzoquinones - pharmacology Benzoquinones - therapeutic use Biological effects Biotechnology Cancer Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Caspase CD44 antigen Cell Line, Tumor Cell lines Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Cells Colonies G1 Phase Cell Cycle Checkpoints - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Kidney cancer kidney carcinoma cells Kidney Neoplasms - drug therapy Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases Male Membrane potential Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred BALB C Mitochondria Neoplasms Neoplastic Stem Cells - cytology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Nestin Oxygen Phagocytosis Proliferation Reactive oxygen species Reactive Oxygen Species - metabolism Renal cell carcinoma stemness Superoxide Surgical implants thymoquinone Tumor cell lines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!