Somatic mutation: The hidden genetics of brain malformations and focal epilepsies

•Review on accumulating evidence for the presence of somatic variants in normal brain tissue.•Review on current understanding of somatic variants in brain malformations associated with lesional epilepsy.•Discussion on strategies to identify the potential contribution of somatic mutation to non-lesio...

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Veröffentlicht in:	Epilepsy research 2019-09, Vol.155, p.106161-106161, Article 106161
Hauptverfasser:	Ye, Zimeng, McQuillan, Lara, Poduri, Annapurna, Green, Timothy E., Matsumoto, Naomichi, Mefford, Heather C., Scheffer, Ingrid E., Berkovic, Samuel F., Hildebrand, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - abnormalities Brain malformations Deep sequencing Epilepsies, Partial - genetics Humans Lesional epilepsies Malformations of Cortical Development - genetics Mosaicism Mutation Somatic mosaicism
Online-Zugang:	Volltext
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