QKI deficiency maintains glioma stem cell stemness by activating the SHH/GLI1 signaling pathway

Purpose Glioblastoma (GBM) stem cells (GSCs) have been found to be the main cause of malignant GBM progression. It has also been found that Quaking homolog (QKI ) plays a predominant role in driving GBM development. Here, we aimed to asses the role of QKI in maintaining GSC stemness and inducing the...

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Veröffentlicht in:	Cellular oncology (Dordrecht) 2019-12, Vol.42 (6), p.801-813
Hauptverfasser:	Han, Bo, Wang, Ruijia, Chen, Yongjie, Meng, Xiangqi, Wu, Pengfei, Li, Ziwei, Duan, Chunbin, Li, Qingbin, Li, Yang, Zhao, Shihong, Jiang, Chuanlu, Cai, Jinquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Biomedical and Life Sciences Biomedicine Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Research Cell Line, Tumor Cell migration Cell Proliferation Cell self-renewal CRISPR Female Gene Expression Regulation, Neoplastic Gli1 protein Glioblastoma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells Hedgehog protein Hedgehog Proteins - metabolism Humans Immunoprecipitation Invasiveness Male Mice, Inbred BALB C Mice, Nude Middle Aged Models, Biological mRNA Neoplasm Invasiveness Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology Original Paper Pathology Phenotype Phosphorylation RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction Stem cell transplantation Stem cells Survival Analysis Xenografts Zinc Finger Protein GLI1 - metabolism Zinc finger proteins
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