Adult vascular dysfunction in foetal growth‐restricted guinea‐pigs is associated with a neonate‐adult switching in Nos3 DNA methylation

Aim Foetal growth restriction (FGR) is associated with endothelial dysfunction and cardiovascular diseases in adult subjects. Early vascular remodelling and epigenetic changes occurring on key endothelial genes might precede this altered vascular function. Further, it has been proposed that oxidativ...

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Veröffentlicht in:	Acta Physiologica 2019-11, Vol.227 (3), p.e13328-n/a
Hauptverfasser:	Krause, Bernardo J., Peñaloza, Estefanía, Candia, Alejandro, Cañas, Daniel, Hernández, Cherie, Arenas, German A., Peralta‐Scholz, María José, Valenzuela, Rodrigo, García‐Herrera, Claudio, Herrera, Emilio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta Cardiovascular diseases Carotid artery Deoxyribonucleic acid DNA DNA methylation Endothelial cells endothelial function Epigenetics Femur foetal growth restriction Mechanical properties mRNA NOS3 Oxidative stress
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