tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression
tRNA‐derived stress‐induced RNAs (tiRNAs), important components of tRNA‐derived fragments, are gaining popularity for their functions as small noncoding RNAs involved in cancer progression. Under cellular stress, tiRNAs are generated when mature tRNA is specifically cleaved by angiogenin and suggest...
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| Veröffentlicht in: | Journal of cellular physiology 2020-02, Vol.235 (2), p.683-690 |
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| container_end_page | 690 |
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| container_title | Journal of cellular physiology |
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| creator | Tao, En‐Wei Cheng, Wing Yin Li, Wei‐Lin Yu, Jun Gao, Qin‐Yan |
| description | tRNA‐derived stress‐induced RNAs (tiRNAs), important components of tRNA‐derived fragments, are gaining popularity for their functions as small noncoding RNAs involved in cancer progression. Under cellular stress, tiRNAs are generated when mature tRNA is specifically cleaved by angiogenin and suggested to act as transducers or effectors involved in cellular stress responses. tiRNAs facilitate cells to respond to stresses mainly via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules. This review introduces the cellular biogenesis, molecular mechanisms, and biological roles of tiRNAs in stress response and disease regulation. A better understanding of their roles in regulating cancer may provide novel biomarkers or therapeutic targets for diagnosis and treatment.
1.
The production of tRNA‐derived stress‐induced RNAs (tiRNAs) is a novel response to cellular stress.
2.
tiRNAs facilitate cells to respond to stresses via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules.
3.
The stress‐angiogenin‐tiRNAs signaling pathway is a novel mechanism to regulate tumorigenesis. |
| doi_str_mv | 10.1002/jcp.29057 |
| format | Article |
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1.
The production of tRNA‐derived stress‐induced RNAs (tiRNAs) is a novel response to cellular stress.
2.
tiRNAs facilitate cells to respond to stresses via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules.
3.
The stress‐angiogenin‐tiRNAs signaling pathway is a novel mechanism to regulate tumorigenesis.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.29057</identifier><identifier>PMID: 31286522</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Angiogenin ; Apoptosis ; Biomarkers ; Cancer ; Cellular stress response ; Molecular modelling ; mRNA ; stress response ; Therapeutic applications ; tiRNAs ; Transducers ; translational reprogramming ; tRNA</subject><ispartof>Journal of cellular physiology, 2020-02, Vol.235 (2), p.683-690</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-3c59a7eb561d44aa0bf4a310a7cffa5f1fd16c7181b78115c9766aa805abfbab3</citedby><cites>FETCH-LOGICAL-c3537-3c59a7eb561d44aa0bf4a310a7cffa5f1fd16c7181b78115c9766aa805abfbab3</cites><orcidid>0000-0001-9422-300X ; 0000-0001-5008-2153</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.29057$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.29057$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31286522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tao, En‐Wei</creatorcontrib><creatorcontrib>Cheng, Wing Yin</creatorcontrib><creatorcontrib>Li, Wei‐Lin</creatorcontrib><creatorcontrib>Yu, Jun</creatorcontrib><creatorcontrib>Gao, Qin‐Yan</creatorcontrib><title>tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>tRNA‐derived stress‐induced RNAs (tiRNAs), important components of tRNA‐derived fragments, are gaining popularity for their functions as small noncoding RNAs involved in cancer progression. Under cellular stress, tiRNAs are generated when mature tRNA is specifically cleaved by angiogenin and suggested to act as transducers or effectors involved in cellular stress responses. tiRNAs facilitate cells to respond to stresses mainly via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules. This review introduces the cellular biogenesis, molecular mechanisms, and biological roles of tiRNAs in stress response and disease regulation. A better understanding of their roles in regulating cancer may provide novel biomarkers or therapeutic targets for diagnosis and treatment.
1.
The production of tRNA‐derived stress‐induced RNAs (tiRNAs) is a novel response to cellular stress.
2.
tiRNAs facilitate cells to respond to stresses via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules.
3.
The stress‐angiogenin‐tiRNAs signaling pathway is a novel mechanism to regulate tumorigenesis.</description><subject>Angiogenin</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Cellular stress response</subject><subject>Molecular modelling</subject><subject>mRNA</subject><subject>stress response</subject><subject>Therapeutic applications</subject><subject>tiRNAs</subject><subject>Transducers</subject><subject>translational reprogramming</subject><subject>tRNA</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10UGL1DAUB_Agiju7evALSMCLHrqb1zRN620YdFUWFdFzeE2T3Q6ZpOZ1lPn2ZpzVg-ApJO_HPw_-jD0DcQlC1FdbO1_WvVD6AVuB6HXVtKp-yFZlBlWvGjhj50RbIUTfS_mYnUmou0LqFTss05ePa3rN1zymHy5wG5CIJ89phyGUx2jTOMVbfmR8ucOF37kwE7cuBOLZ0ZziyJfEaSkXSpk4loc54KGMU3DEp8gtRusyn3O6PaopxSfskcdA7un9ecG-vX3zdfOuuvl0_X6zvqmsVFJX0qoetRtUC2PTIIrBNyhBoLbeo_LgR2ithg4G3QEo2-u2ReyEwsEPOMgL9vKUW_7-vne0mN1Ex-UxurQnU9eqUdAJKQt98Q_dpn2OZTtTS9CqbRpoinp1UjYnouy8mfO0w3wwIMyxD1P6ML_7KPb5feJ-2Lnxr_xTQAFXJ_BzCu7w_yTzYfP5FPkLu7SU_Q</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Tao, En‐Wei</creator><creator>Cheng, Wing Yin</creator><creator>Li, Wei‐Lin</creator><creator>Yu, Jun</creator><creator>Gao, Qin‐Yan</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9422-300X</orcidid><orcidid>https://orcid.org/0000-0001-5008-2153</orcidid></search><sort><creationdate>202002</creationdate><title>tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression</title><author>Tao, En‐Wei ; Cheng, Wing Yin ; Li, Wei‐Lin ; Yu, Jun ; Gao, Qin‐Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-3c59a7eb561d44aa0bf4a310a7cffa5f1fd16c7181b78115c9766aa805abfbab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiogenin</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Cellular stress response</topic><topic>Molecular modelling</topic><topic>mRNA</topic><topic>stress response</topic><topic>Therapeutic applications</topic><topic>tiRNAs</topic><topic>Transducers</topic><topic>translational reprogramming</topic><topic>tRNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tao, En‐Wei</creatorcontrib><creatorcontrib>Cheng, Wing Yin</creatorcontrib><creatorcontrib>Li, Wei‐Lin</creatorcontrib><creatorcontrib>Yu, Jun</creatorcontrib><creatorcontrib>Gao, Qin‐Yan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tao, En‐Wei</au><au>Cheng, Wing Yin</au><au>Li, Wei‐Lin</au><au>Yu, Jun</au><au>Gao, Qin‐Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2020-02</date><risdate>2020</risdate><volume>235</volume><issue>2</issue><spage>683</spage><epage>690</epage><pages>683-690</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>tRNA‐derived stress‐induced RNAs (tiRNAs), important components of tRNA‐derived fragments, are gaining popularity for their functions as small noncoding RNAs involved in cancer progression. Under cellular stress, tiRNAs are generated when mature tRNA is specifically cleaved by angiogenin and suggested to act as transducers or effectors involved in cellular stress responses. tiRNAs facilitate cells to respond to stresses mainly via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules. This review introduces the cellular biogenesis, molecular mechanisms, and biological roles of tiRNAs in stress response and disease regulation. A better understanding of their roles in regulating cancer may provide novel biomarkers or therapeutic targets for diagnosis and treatment.
1.
The production of tRNA‐derived stress‐induced RNAs (tiRNAs) is a novel response to cellular stress.
2.
tiRNAs facilitate cells to respond to stresses via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules.
3.
The stress‐angiogenin‐tiRNAs signaling pathway is a novel mechanism to regulate tumorigenesis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31286522</pmid><doi>10.1002/jcp.29057</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9422-300X</orcidid><orcidid>https://orcid.org/0000-0001-5008-2153</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Journals |
| subjects | Angiogenin Apoptosis Biomarkers Cancer Cellular stress response Molecular modelling mRNA stress response Therapeutic applications tiRNAs Transducers translational reprogramming tRNA |
| title | tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression |
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