Oncological outcomes of CO2 laser cordectomies for glottic squamous cell carcinoma with respect to anterior commissure involvement and margin status
Background and Objectives Controversial prognostic factors of primary CO2 laser cordectomy are anterior commissure involvement (ACI) and status of margin. Study Design/Materials and Methods Retrospective analysis of oncological outcomes in 102 patients with early glottic cancer undergoing laser cord...
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| Veröffentlicht in: | Lasers in surgery and medicine 2019-12, Vol.51 (10), p.874-881 |
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| container_title | Lasers in surgery and medicine |
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| creator | Osuch‐Wójcikiewicz, Ewa Rzepakowska, Anna Sobol, Maria Bruzgielewicz, Antoni Niemczyk, Kazimierz |
| description | Background and Objectives
Controversial prognostic factors of primary CO2 laser cordectomy are anterior commissure involvement (ACI) and status of margin.
Study Design/Materials and Methods
Retrospective analysis of oncological outcomes in 102 patients with early glottic cancer undergoing laser cordectomy between 2013 and 2015.
Results
The T stages distribution included: 72.6% T1a, 14.7% T1b, and 12.7% T2. The ACI was diagnosed in 26 patients. The primary cordectomy was radical in 72 patients. The 2‐ and 5‐year disease free survival (DFS) for all patients were, respectively, 83.3% and 77.3%.The 2‐year DFS rates for T1a, T1b, T2 were, respectively, 91.7%, 66.7%, and 53.9% and the differences were statistically significant (P |
| doi_str_mv | 10.1002/lsm.23130 |
| format | Article |
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Controversial prognostic factors of primary CO2 laser cordectomy are anterior commissure involvement (ACI) and status of margin.
Study Design/Materials and Methods
Retrospective analysis of oncological outcomes in 102 patients with early glottic cancer undergoing laser cordectomy between 2013 and 2015.
Results
The T stages distribution included: 72.6% T1a, 14.7% T1b, and 12.7% T2. The ACI was diagnosed in 26 patients. The primary cordectomy was radical in 72 patients. The 2‐ and 5‐year disease free survival (DFS) for all patients were, respectively, 83.3% and 77.3%.The 2‐year DFS rates for T1a, T1b, T2 were, respectively, 91.7%, 66.7%, and 53.9% and the differences were statistically significant (P < 0.001). The 2‐year DFS rates according to the ACI and free anterior commissure tumors were, respectively, 65.4% and 89.2%, and the ACI indicated worse prognosis (P = 0.057). The 2‐year DFS rates according to margins status were higher for patients with close or positive margins, who had second resection (88.9%) compared with those of negative margins (80.9%) (P = 0.340). Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.23130</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Anterior commissure ; Cancer ; Carbon dioxide ; Carbon dioxide lasers ; CO2 laser ; cordectomy ; glottic cancer ; Laryngeal cancer ; larynx ; Lasers ; Medical prognosis ; Squamous cell carcinoma ; Statistical analysis ; Tumors ; vocal fold</subject><ispartof>Lasers in surgery and medicine, 2019-12, Vol.51 (10), p.874-881</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-4012-8271</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.23130$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.23130$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Osuch‐Wójcikiewicz, Ewa</creatorcontrib><creatorcontrib>Rzepakowska, Anna</creatorcontrib><creatorcontrib>Sobol, Maria</creatorcontrib><creatorcontrib>Bruzgielewicz, Antoni</creatorcontrib><creatorcontrib>Niemczyk, Kazimierz</creatorcontrib><title>Oncological outcomes of CO2 laser cordectomies for glottic squamous cell carcinoma with respect to anterior commissure involvement and margin status</title><title>Lasers in surgery and medicine</title><description>Background and Objectives
Controversial prognostic factors of primary CO2 laser cordectomy are anterior commissure involvement (ACI) and status of margin.
Study Design/Materials and Methods
Retrospective analysis of oncological outcomes in 102 patients with early glottic cancer undergoing laser cordectomy between 2013 and 2015.
Results
The T stages distribution included: 72.6% T1a, 14.7% T1b, and 12.7% T2. The ACI was diagnosed in 26 patients. The primary cordectomy was radical in 72 patients. The 2‐ and 5‐year disease free survival (DFS) for all patients were, respectively, 83.3% and 77.3%.The 2‐year DFS rates for T1a, T1b, T2 were, respectively, 91.7%, 66.7%, and 53.9% and the differences were statistically significant (P < 0.001). The 2‐year DFS rates according to the ACI and free anterior commissure tumors were, respectively, 65.4% and 89.2%, and the ACI indicated worse prognosis (P = 0.057). The 2‐year DFS rates according to margins status were higher for patients with close or positive margins, who had second resection (88.9%) compared with those of negative margins (80.9%) (P = 0.340). Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.</description><subject>Anterior commissure</subject><subject>Cancer</subject><subject>Carbon dioxide</subject><subject>Carbon dioxide lasers</subject><subject>CO2 laser</subject><subject>cordectomy</subject><subject>glottic cancer</subject><subject>Laryngeal cancer</subject><subject>larynx</subject><subject>Lasers</subject><subject>Medical prognosis</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Tumors</subject><subject>vocal fold</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkc1KAzEUhYMoWKsL3yDgxs20SeavWUrxDypdqOuQZu7UlGQyTTItfQ8f2NS6cnUP3O8e7uEgdEvJhBLCpibYCctpTs7QiBJeZZwSeo5GhCY9I5xdoqsQNoSQnJF6hL6XnXLGrbWSBrshKmchYNfi-ZJhIwN4rJxvQEVnddq0zuO1cTFqhcN2kNYNASswBivple6clXiv4xf2EPp0haPDsovgtTs6WatDGDxg3e2c2YGFLqZ9g630a93hEGUcwjW6aKUJcPM3x-jz6fFj_pItls-v84dF1rOyIlnVzFilagbFihZSARRFW1DZNFJWCngLsqlXlLRt0VZMNZyrktECqorQuuR8lY_R_cm39247QIgivXcMIztIuQRjZVHSms94Qu_-oRs3-C59J1ieOJ4s60RNT9ReGziI3uuU6yAoEcdyRCpH_JYjFu9vvyL_AYt8h_E</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Osuch‐Wójcikiewicz, Ewa</creator><creator>Rzepakowska, Anna</creator><creator>Sobol, Maria</creator><creator>Bruzgielewicz, Antoni</creator><creator>Niemczyk, Kazimierz</creator><general>Wiley Subscription Services, Inc</general><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4012-8271</orcidid></search><sort><creationdate>201912</creationdate><title>Oncological outcomes of CO2 laser cordectomies for glottic squamous cell carcinoma with respect to anterior commissure involvement and margin status</title><author>Osuch‐Wójcikiewicz, Ewa ; Rzepakowska, Anna ; Sobol, Maria ; Bruzgielewicz, Antoni ; Niemczyk, Kazimierz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2560-6d826c72e4b14acee44f41addaa6ce9fead7b10ff4f62cd99c5214e66017599b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anterior commissure</topic><topic>Cancer</topic><topic>Carbon dioxide</topic><topic>Carbon dioxide lasers</topic><topic>CO2 laser</topic><topic>cordectomy</topic><topic>glottic cancer</topic><topic>Laryngeal cancer</topic><topic>larynx</topic><topic>Lasers</topic><topic>Medical prognosis</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Tumors</topic><topic>vocal fold</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osuch‐Wójcikiewicz, Ewa</creatorcontrib><creatorcontrib>Rzepakowska, Anna</creatorcontrib><creatorcontrib>Sobol, Maria</creatorcontrib><creatorcontrib>Bruzgielewicz, Antoni</creatorcontrib><creatorcontrib>Niemczyk, Kazimierz</creatorcontrib><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osuch‐Wójcikiewicz, Ewa</au><au>Rzepakowska, Anna</au><au>Sobol, Maria</au><au>Bruzgielewicz, Antoni</au><au>Niemczyk, Kazimierz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncological outcomes of CO2 laser cordectomies for glottic squamous cell carcinoma with respect to anterior commissure involvement and margin status</atitle><jtitle>Lasers in surgery and medicine</jtitle><date>2019-12</date><risdate>2019</risdate><volume>51</volume><issue>10</issue><spage>874</spage><epage>881</epage><pages>874-881</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><abstract>Background and Objectives
Controversial prognostic factors of primary CO2 laser cordectomy are anterior commissure involvement (ACI) and status of margin.
Study Design/Materials and Methods
Retrospective analysis of oncological outcomes in 102 patients with early glottic cancer undergoing laser cordectomy between 2013 and 2015.
Results
The T stages distribution included: 72.6% T1a, 14.7% T1b, and 12.7% T2. The ACI was diagnosed in 26 patients. The primary cordectomy was radical in 72 patients. The 2‐ and 5‐year disease free survival (DFS) for all patients were, respectively, 83.3% and 77.3%.The 2‐year DFS rates for T1a, T1b, T2 were, respectively, 91.7%, 66.7%, and 53.9% and the differences were statistically significant (P < 0.001). The 2‐year DFS rates according to the ACI and free anterior commissure tumors were, respectively, 65.4% and 89.2%, and the ACI indicated worse prognosis (P = 0.057). The 2‐year DFS rates according to margins status were higher for patients with close or positive margins, who had second resection (88.9%) compared with those of negative margins (80.9%) (P = 0.340). Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/lsm.23130</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4012-8271</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anterior commissure Cancer Carbon dioxide Carbon dioxide lasers CO2 laser cordectomy glottic cancer Laryngeal cancer larynx Lasers Medical prognosis Squamous cell carcinoma Statistical analysis Tumors vocal fold |
| title | Oncological outcomes of CO2 laser cordectomies for glottic squamous cell carcinoma with respect to anterior commissure involvement and margin status |
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