Safety screening in early drug discovery: An optimized assay panel

Several factors contribute to the development failure of novel pharmaceuticals, one of the most important being adverse effects in pre-clinical and clinical studies. Early identification of off-target compound activity can reduce safety-related attrition in development. In vitro profiling of drug ca...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2019-09, Vol.99, p.106609-106609, Article 106609
Hauptverfasser:	Bendels, Stefanie, Bissantz, Caterina, Fasching, Bernhard, Gerebtzoff, Grégori, Guba, Wolfgang, Kansy, Manfred, Migeon, Jacques, Mohr, Susanne, Peters, Jens-Uwe, Tillier, Fabien, Wyler, René, Lerner, Christian, Kramer, Christian, Richter, Hans, Roberts, Sonia
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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