Overcoming genetic heterogeneity in industrial fermentations

Engineering the synthesis of massive amounts of therapeutics, enzymes or commodity chemicals can select for subpopulations of nonproducer cells, owing to metabolic burden and product toxicity. Deep DNA sequencing can be used to detect undesirable genetic heterogeneity in producer populations and dia...

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Veröffentlicht in:	Nature biotechnology 2019-08, Vol.37 (8), p.869-876
Hauptverfasser:	Rugbjerg, Peter, Sommer, Morten O. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/181/457 631/326/252 631/61/318 631/61/514/2254 Agriculture Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Deoxyribonucleic acid DNA DNA sequencing Error detection Heterogeneity Life Sciences Metabolic engineering Metabolism Nonproducer cells Organic chemistry Perspective Population genetics Subpopulations Toxicity
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