Gamma radiation-induced crosslinked composite membranes based on polyvinyl alcohol/chitosan/AgNO3/vitamin E for biomedical applications
Crosslinked hydrogel composite membranes based on polyvinyl alcohol (PVA) and chitosan-loaded AgNO3 and vitamin E were prepared using gamma irradiation. Chitosan has been used as antimicrobial blend materials to provide further biocompatibility for the prepared composite hydrogel membranes. The cros...
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| Veröffentlicht in: | International journal of biological macromolecules 2019-09, Vol.137, p.878-885 |
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| creator | Nasef, Shaimaa M. Khozemy, Ehab E. Kamoun, Elbadawy A. El-Gendi, H. |
| description | Crosslinked hydrogel composite membranes based on polyvinyl alcohol (PVA) and chitosan-loaded AgNO3 and vitamin E were prepared using gamma irradiation. Chitosan has been used as antimicrobial blend materials to provide further biocompatibility for the prepared composite hydrogel membranes. The crosslinking reaction between PVA and chitosan owing to gamma irradiation was verified and characterized by FTIR analysis, while the morphology of hydrogel composite membranes was investigated by SEM. Important parameters affecting on hydrogel membranes formation, such as copolymer concentration, irradiation dose, AgNO3 concentration, plasticizer, and vitamin E of PVA/chitosan membranes were evaluated and discussed in details. In addition, the mechanical and thermal properties of hydrogel composite membranes were examined to evaluate the possibility of its application for wound dressings. The results revealed that the gelation (%) of hydrogel membranes increased dramatically with PVA composition, irradiation dose and glycerol content up to 20%; however, it decreased with AgNP incorporation due to the viscosity of copolymer composition is hyper-increased. The swelling ratio of composed hydrogel membranes decreased notably with increasing the radiation dose and incorporation of AgNP, due to reducing of the crosslinking degree of formed hydrogel membranes. PVA-Cs-Ag composed hydrogel membranes showed significant antimicrobial activity in particular against Streptococcus mutans due to the presence of AgNP in membranes, compared to other bacteria and fungi microbes. Thus, the PVA/chitosan/AgNO3-Vit.E hydrogel composite membranes showed satisfactory properties for use as wound dressing materials.
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•A green synthesis of economic nanocomposite based on on PVA/Cs/Ag/Vit E was prepared by gamma radiation.•High-performance nanocomposite was obtained and confirmed with FTIR, XRD and TEM.•Good mechanical and thermal stability•Significant antimicrobial activity in particular against Streptococcus mutans due to the presence of AgNP in membranes.•These nanocomposite membranes can potentially be applied in biomedical applications such as wound dressing. |
| doi_str_mv | 10.1016/j.ijbiomac.2019.07.033 |
| format | Article |
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[Display omitted]
•A green synthesis of economic nanocomposite based on on PVA/Cs/Ag/Vit E was prepared by gamma radiation.•High-performance nanocomposite was obtained and confirmed with FTIR, XRD and TEM.•Good mechanical and thermal stability•Significant antimicrobial activity in particular against Streptococcus mutans due to the presence of AgNP in membranes.•These nanocomposite membranes can potentially be applied in biomedical applications such as wound dressing.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2019.07.033</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Gamma irradiation ; Hydrogel composite membrane ; PVA/chitosan ; Wound dressing</subject><ispartof>International journal of biological macromolecules, 2019-09, Vol.137, p.878-885</ispartof><rights>2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-325bc0c49653cc3f0c3199858e56880ff2fc9d6237f9d15dcf2d8dfe05e84c353</citedby><cites>FETCH-LOGICAL-c345t-325bc0c49653cc3f0c3199858e56880ff2fc9d6237f9d15dcf2d8dfe05e84c353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2019.07.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Nasef, Shaimaa M.</creatorcontrib><creatorcontrib>Khozemy, Ehab E.</creatorcontrib><creatorcontrib>Kamoun, Elbadawy A.</creatorcontrib><creatorcontrib>El-Gendi, H.</creatorcontrib><title>Gamma radiation-induced crosslinked composite membranes based on polyvinyl alcohol/chitosan/AgNO3/vitamin E for biomedical applications</title><title>International journal of biological macromolecules</title><description>Crosslinked hydrogel composite membranes based on polyvinyl alcohol (PVA) and chitosan-loaded AgNO3 and vitamin E were prepared using gamma irradiation. Chitosan has been used as antimicrobial blend materials to provide further biocompatibility for the prepared composite hydrogel membranes. The crosslinking reaction between PVA and chitosan owing to gamma irradiation was verified and characterized by FTIR analysis, while the morphology of hydrogel composite membranes was investigated by SEM. Important parameters affecting on hydrogel membranes formation, such as copolymer concentration, irradiation dose, AgNO3 concentration, plasticizer, and vitamin E of PVA/chitosan membranes were evaluated and discussed in details. In addition, the mechanical and thermal properties of hydrogel composite membranes were examined to evaluate the possibility of its application for wound dressings. The results revealed that the gelation (%) of hydrogel membranes increased dramatically with PVA composition, irradiation dose and glycerol content up to 20%; however, it decreased with AgNP incorporation due to the viscosity of copolymer composition is hyper-increased. The swelling ratio of composed hydrogel membranes decreased notably with increasing the radiation dose and incorporation of AgNP, due to reducing of the crosslinking degree of formed hydrogel membranes. PVA-Cs-Ag composed hydrogel membranes showed significant antimicrobial activity in particular against Streptococcus mutans due to the presence of AgNP in membranes, compared to other bacteria and fungi microbes. Thus, the PVA/chitosan/AgNO3-Vit.E hydrogel composite membranes showed satisfactory properties for use as wound dressing materials.
[Display omitted]
•A green synthesis of economic nanocomposite based on on PVA/Cs/Ag/Vit E was prepared by gamma radiation.•High-performance nanocomposite was obtained and confirmed with FTIR, XRD and TEM.•Good mechanical and thermal stability•Significant antimicrobial activity in particular against Streptococcus mutans due to the presence of AgNP in membranes.•These nanocomposite membranes can potentially be applied in biomedical applications such as wound dressing.</description><subject>Gamma irradiation</subject><subject>Hydrogel composite membrane</subject><subject>PVA/chitosan</subject><subject>Wound dressing</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkMtu1DAUhi1EJYa2r4C8ZJOMHceJs6OqSkGq2g1dW55jm3rwJdiZkeYJeO06DKy7Or_O-c_tQ-gTJS0ldNjuW7ffuRQUtB2hU0vGljD2Dm2oGKeGEMLeow2hPW0EZeQD-ljKvmYHTsUG_blXISiclXZqcSk2LuoDGI0hp1K8i79WncKcilsMDibssoqm4J0qtZIinpM_HV08eaw8pJfkt_DillRU3N78fHxi26NbVHAR32GbMl4vNdqBqv559lWsa8sVurDKF3P9L16i5693P26_NQ9P999vbx4aYD1fGtbxHRDop4EzAGYJMDpNggvDByGItZ2FSQ8dG-2kKddgOy20NYQb0QPj7BJ9Ps-dc_p9MGWRwRUw3ten0qHIruM9J93IRbUOZ-tfFNlYOWcXVD5JSuRKXu7lf_JyJS_JKCv52vjl3GjqI0dnsizgTKxUXTawSJ3cWyNeAYQHk0Y</recordid><startdate>20190915</startdate><enddate>20190915</enddate><creator>Nasef, Shaimaa M.</creator><creator>Khozemy, Ehab E.</creator><creator>Kamoun, Elbadawy A.</creator><creator>El-Gendi, H.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190915</creationdate><title>Gamma radiation-induced crosslinked composite membranes based on polyvinyl alcohol/chitosan/AgNO3/vitamin E for biomedical applications</title><author>Nasef, Shaimaa M. ; Khozemy, Ehab E. ; Kamoun, Elbadawy A. ; El-Gendi, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-325bc0c49653cc3f0c3199858e56880ff2fc9d6237f9d15dcf2d8dfe05e84c353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Gamma irradiation</topic><topic>Hydrogel composite membrane</topic><topic>PVA/chitosan</topic><topic>Wound dressing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasef, Shaimaa M.</creatorcontrib><creatorcontrib>Khozemy, Ehab E.</creatorcontrib><creatorcontrib>Kamoun, Elbadawy A.</creatorcontrib><creatorcontrib>El-Gendi, H.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasef, Shaimaa M.</au><au>Khozemy, Ehab E.</au><au>Kamoun, Elbadawy A.</au><au>El-Gendi, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gamma radiation-induced crosslinked composite membranes based on polyvinyl alcohol/chitosan/AgNO3/vitamin E for biomedical applications</atitle><jtitle>International journal of biological macromolecules</jtitle><date>2019-09-15</date><risdate>2019</risdate><volume>137</volume><spage>878</spage><epage>885</epage><pages>878-885</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Crosslinked hydrogel composite membranes based on polyvinyl alcohol (PVA) and chitosan-loaded AgNO3 and vitamin E were prepared using gamma irradiation. Chitosan has been used as antimicrobial blend materials to provide further biocompatibility for the prepared composite hydrogel membranes. The crosslinking reaction between PVA and chitosan owing to gamma irradiation was verified and characterized by FTIR analysis, while the morphology of hydrogel composite membranes was investigated by SEM. Important parameters affecting on hydrogel membranes formation, such as copolymer concentration, irradiation dose, AgNO3 concentration, plasticizer, and vitamin E of PVA/chitosan membranes were evaluated and discussed in details. In addition, the mechanical and thermal properties of hydrogel composite membranes were examined to evaluate the possibility of its application for wound dressings. The results revealed that the gelation (%) of hydrogel membranes increased dramatically with PVA composition, irradiation dose and glycerol content up to 20%; however, it decreased with AgNP incorporation due to the viscosity of copolymer composition is hyper-increased. The swelling ratio of composed hydrogel membranes decreased notably with increasing the radiation dose and incorporation of AgNP, due to reducing of the crosslinking degree of formed hydrogel membranes. PVA-Cs-Ag composed hydrogel membranes showed significant antimicrobial activity in particular against Streptococcus mutans due to the presence of AgNP in membranes, compared to other bacteria and fungi microbes. Thus, the PVA/chitosan/AgNO3-Vit.E hydrogel composite membranes showed satisfactory properties for use as wound dressing materials.
[Display omitted]
•A green synthesis of economic nanocomposite based on on PVA/Cs/Ag/Vit E was prepared by gamma radiation.•High-performance nanocomposite was obtained and confirmed with FTIR, XRD and TEM.•Good mechanical and thermal stability•Significant antimicrobial activity in particular against Streptococcus mutans due to the presence of AgNP in membranes.•These nanocomposite membranes can potentially be applied in biomedical applications such as wound dressing.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.ijbiomac.2019.07.033</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Gamma irradiation Hydrogel composite membrane PVA/chitosan Wound dressing |
| title | Gamma radiation-induced crosslinked composite membranes based on polyvinyl alcohol/chitosan/AgNO3/vitamin E for biomedical applications |
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