Comorbid psychiatric disorders among patients with narcolepsy
Purpose This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview. Methods The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made accord...
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| Veröffentlicht in: | Sleep & breathing 2020-06, Vol.24 (2), p.629-636 |
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| creator | Alasim, Haithm AlQazlan, Salman Albanyan, Saleh Alsalhi, Abdulaziz Buraik, Alwalid Olaish, Awad H. Almeneessier, Aljohara S. Alosaimi, Fahad D. AlHadi, Ahmad BaHammam, Ahmed S. |
| description | Purpose
This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview.
Methods
The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition. Psychiatric disorders were diagnosed via using a validated Arabic version of the Mini International Neuropsychiatric Interview DSM-IV (MINI version 6). A multivariate logistic regression model was used to assess the potential influence of narcolepsy on the comorbidity of psychiatric disorders.
Results
The mean age of the patients was 29.4 ± 10.2 years, and males accounted for 81% of the study sample. Forty-four patients (60%) were diagnosed with narcolepsy type-1 (NT1) and 30 (40%) with narcolepsy type-2 (NT2). Psychiatric disorders were diagnosed in 45% of patients with narcolepsy compared with 15% of the controls (
p
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| doi_str_mv | 10.1007/s11325-019-01890-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2253832873</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2253832873</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e5019d19644bc8ed1ab553ceab5c084eeac632775d75b5cf986b51574d3b4fbe3</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EoqXwBxhQJBaWgK8ftTMwoIqXVIkFZstxnDZVEgc7Eeq_x214SAwM1rXs75x7dBA6B3wNGIubAEAJTzFk8cgMp_IATYETkoLA2eH-jtOMA5mgkxA2GAOTGRyjCQUiMcMwRbcL1zifV0XSha1ZV7r3lUmKKjhfWB8S3bh2lXS6r2zbh-Sj6tdJq71xtY2CU3RU6jrYs685Q28P96-Lp3T58vi8uFumhgrep5bHjAVkc8ZyI20BOuecGhuHwZJZq82cEiF4IXh8KjM5zzlwwQqaszK3dIauRt_Ou_fBhl41VTC2rnVr3RAUIZxKSqSgEb38g27c4NuYbkcRAQxjFikyUsa7ELwtVeerRvutAqx25aqxXBWDq325SkbRxZf1kDe2-JF8txkBOgIhfrUr6393_2P7CZvLhGI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2252714004</pqid></control><display><type>article</type><title>Comorbid psychiatric disorders among patients with narcolepsy</title><source>Springer Nature - Complete Springer Journals</source><creator>Alasim, Haithm ; AlQazlan, Salman ; Albanyan, Saleh ; Alsalhi, Abdulaziz ; Buraik, Alwalid ; Olaish, Awad H. ; Almeneessier, Aljohara S. ; Alosaimi, Fahad D. ; AlHadi, Ahmad ; BaHammam, Ahmed S.</creator><creatorcontrib>Alasim, Haithm ; AlQazlan, Salman ; Albanyan, Saleh ; Alsalhi, Abdulaziz ; Buraik, Alwalid ; Olaish, Awad H. ; Almeneessier, Aljohara S. ; Alosaimi, Fahad D. ; AlHadi, Ahmad ; BaHammam, Ahmed S.</creatorcontrib><description>Purpose
This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview.
Methods
The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition. Psychiatric disorders were diagnosed via using a validated Arabic version of the Mini International Neuropsychiatric Interview DSM-IV (MINI version 6). A multivariate logistic regression model was used to assess the potential influence of narcolepsy on the comorbidity of psychiatric disorders.
Results
The mean age of the patients was 29.4 ± 10.2 years, and males accounted for 81% of the study sample. Forty-four patients (60%) were diagnosed with narcolepsy type-1 (NT1) and 30 (40%) with narcolepsy type-2 (NT2). Psychiatric disorders were diagnosed in 45% of patients with narcolepsy compared with 15% of the controls (
p
< 0.001). The multivariate logistic regression models demonstrated that compared with the controls, patients with narcolepsy were more likely to have major depressive disorders (OR, 4.3 [CI, 2.2–8.2]), and generalized anxiety disorders (OR, 9.5 [CI, 1.8–50.2]). No difference was detected between the prevalence of various psychiatric disorders in patients with NT1 and NT2.
Conclusion
Comorbid psychiatric disorders are common among Arab (Saudi) patients with narcolepsy compared with the general population. Therefore, clinicians should be aware of the comorbidity of narcolepsy and psychiatric disorders, particularly depression.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-019-01890-8</identifier><identifier>PMID: 31280401</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Anxiety ; Comorbidity ; Dentistry ; Health risk assessment ; Internal Medicine ; Medicine ; Medicine & Public Health ; Mental depression ; Mental disorders ; Narcolepsy ; Neurology ; Neurology • Original Article ; Neurotrophin 1 ; Neurotrophin 2 ; Otorhinolaryngology ; Pediatrics ; Pneumology/Respiratory System ; Regression analysis ; Sleep ; Sleep disorders</subject><ispartof>Sleep & breathing, 2020-06, Vol.24 (2), p.629-636</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>Springer Nature Switzerland AG 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e5019d19644bc8ed1ab553ceab5c084eeac632775d75b5cf986b51574d3b4fbe3</citedby><cites>FETCH-LOGICAL-c375t-e5019d19644bc8ed1ab553ceab5c084eeac632775d75b5cf986b51574d3b4fbe3</cites><orcidid>0000-0002-1706-6167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-019-01890-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-019-01890-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31280401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alasim, Haithm</creatorcontrib><creatorcontrib>AlQazlan, Salman</creatorcontrib><creatorcontrib>Albanyan, Saleh</creatorcontrib><creatorcontrib>Alsalhi, Abdulaziz</creatorcontrib><creatorcontrib>Buraik, Alwalid</creatorcontrib><creatorcontrib>Olaish, Awad H.</creatorcontrib><creatorcontrib>Almeneessier, Aljohara S.</creatorcontrib><creatorcontrib>Alosaimi, Fahad D.</creatorcontrib><creatorcontrib>AlHadi, Ahmad</creatorcontrib><creatorcontrib>BaHammam, Ahmed S.</creatorcontrib><title>Comorbid psychiatric disorders among patients with narcolepsy</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Purpose
This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview.
Methods
The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition. Psychiatric disorders were diagnosed via using a validated Arabic version of the Mini International Neuropsychiatric Interview DSM-IV (MINI version 6). A multivariate logistic regression model was used to assess the potential influence of narcolepsy on the comorbidity of psychiatric disorders.
Results
The mean age of the patients was 29.4 ± 10.2 years, and males accounted for 81% of the study sample. Forty-four patients (60%) were diagnosed with narcolepsy type-1 (NT1) and 30 (40%) with narcolepsy type-2 (NT2). Psychiatric disorders were diagnosed in 45% of patients with narcolepsy compared with 15% of the controls (
p
< 0.001). The multivariate logistic regression models demonstrated that compared with the controls, patients with narcolepsy were more likely to have major depressive disorders (OR, 4.3 [CI, 2.2–8.2]), and generalized anxiety disorders (OR, 9.5 [CI, 1.8–50.2]). No difference was detected between the prevalence of various psychiatric disorders in patients with NT1 and NT2.
Conclusion
Comorbid psychiatric disorders are common among Arab (Saudi) patients with narcolepsy compared with the general population. Therefore, clinicians should be aware of the comorbidity of narcolepsy and psychiatric disorders, particularly depression.</description><subject>Anxiety</subject><subject>Comorbidity</subject><subject>Dentistry</subject><subject>Health risk assessment</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Narcolepsy</subject><subject>Neurology</subject><subject>Neurology • Original Article</subject><subject>Neurotrophin 1</subject><subject>Neurotrophin 2</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Regression analysis</subject><subject>Sleep</subject><subject>Sleep disorders</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kDtPwzAUhS0EoqXwBxhQJBaWgK8ftTMwoIqXVIkFZstxnDZVEgc7Eeq_x214SAwM1rXs75x7dBA6B3wNGIubAEAJTzFk8cgMp_IATYETkoLA2eH-jtOMA5mgkxA2GAOTGRyjCQUiMcMwRbcL1zifV0XSha1ZV7r3lUmKKjhfWB8S3bh2lXS6r2zbh-Sj6tdJq71xtY2CU3RU6jrYs685Q28P96-Lp3T58vi8uFumhgrep5bHjAVkc8ZyI20BOuecGhuHwZJZq82cEiF4IXh8KjM5zzlwwQqaszK3dIauRt_Ou_fBhl41VTC2rnVr3RAUIZxKSqSgEb38g27c4NuYbkcRAQxjFikyUsa7ELwtVeerRvutAqx25aqxXBWDq325SkbRxZf1kDe2-JF8txkBOgIhfrUr6393_2P7CZvLhGI</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Alasim, Haithm</creator><creator>AlQazlan, Salman</creator><creator>Albanyan, Saleh</creator><creator>Alsalhi, Abdulaziz</creator><creator>Buraik, Alwalid</creator><creator>Olaish, Awad H.</creator><creator>Almeneessier, Aljohara S.</creator><creator>Alosaimi, Fahad D.</creator><creator>AlHadi, Ahmad</creator><creator>BaHammam, Ahmed S.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>POGQB</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRQQA</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1706-6167</orcidid></search><sort><creationdate>20200601</creationdate><title>Comorbid psychiatric disorders among patients with narcolepsy</title><author>Alasim, Haithm ; AlQazlan, Salman ; Albanyan, Saleh ; Alsalhi, Abdulaziz ; Buraik, Alwalid ; Olaish, Awad H. ; Almeneessier, Aljohara S. ; Alosaimi, Fahad D. ; AlHadi, Ahmad ; BaHammam, Ahmed S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e5019d19644bc8ed1ab553ceab5c084eeac632775d75b5cf986b51574d3b4fbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anxiety</topic><topic>Comorbidity</topic><topic>Dentistry</topic><topic>Health risk assessment</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Narcolepsy</topic><topic>Neurology</topic><topic>Neurology • Original Article</topic><topic>Neurotrophin 1</topic><topic>Neurotrophin 2</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Regression analysis</topic><topic>Sleep</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alasim, Haithm</creatorcontrib><creatorcontrib>AlQazlan, Salman</creatorcontrib><creatorcontrib>Albanyan, Saleh</creatorcontrib><creatorcontrib>Alsalhi, Abdulaziz</creatorcontrib><creatorcontrib>Buraik, Alwalid</creatorcontrib><creatorcontrib>Olaish, Awad H.</creatorcontrib><creatorcontrib>Almeneessier, Aljohara S.</creatorcontrib><creatorcontrib>Alosaimi, Fahad D.</creatorcontrib><creatorcontrib>AlHadi, Ahmad</creatorcontrib><creatorcontrib>BaHammam, Ahmed S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest Sociology & Social Sciences Collection</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Social Sciences</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alasim, Haithm</au><au>AlQazlan, Salman</au><au>Albanyan, Saleh</au><au>Alsalhi, Abdulaziz</au><au>Buraik, Alwalid</au><au>Olaish, Awad H.</au><au>Almeneessier, Aljohara S.</au><au>Alosaimi, Fahad D.</au><au>AlHadi, Ahmad</au><au>BaHammam, Ahmed S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comorbid psychiatric disorders among patients with narcolepsy</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>24</volume><issue>2</issue><spage>629</spage><epage>636</epage><pages>629-636</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Purpose
This case-control study assessed the prevalence of psychiatric disorders in Arab (Saudi) patients with narcolepsy using a structured clinical interview.
Methods
The study included 74 adult patients with narcolepsy and 265 controls matched for age and sex. Narcolepsy diagnosis was made according to the International Classification of Sleep Disorders-Third Edition. Psychiatric disorders were diagnosed via using a validated Arabic version of the Mini International Neuropsychiatric Interview DSM-IV (MINI version 6). A multivariate logistic regression model was used to assess the potential influence of narcolepsy on the comorbidity of psychiatric disorders.
Results
The mean age of the patients was 29.4 ± 10.2 years, and males accounted for 81% of the study sample. Forty-four patients (60%) were diagnosed with narcolepsy type-1 (NT1) and 30 (40%) with narcolepsy type-2 (NT2). Psychiatric disorders were diagnosed in 45% of patients with narcolepsy compared with 15% of the controls (
p
< 0.001). The multivariate logistic regression models demonstrated that compared with the controls, patients with narcolepsy were more likely to have major depressive disorders (OR, 4.3 [CI, 2.2–8.2]), and generalized anxiety disorders (OR, 9.5 [CI, 1.8–50.2]). No difference was detected between the prevalence of various psychiatric disorders in patients with NT1 and NT2.
Conclusion
Comorbid psychiatric disorders are common among Arab (Saudi) patients with narcolepsy compared with the general population. Therefore, clinicians should be aware of the comorbidity of narcolepsy and psychiatric disorders, particularly depression.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31280401</pmid><doi>10.1007/s11325-019-01890-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1706-6167</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Anxiety Comorbidity Dentistry Health risk assessment Internal Medicine Medicine Medicine & Public Health Mental depression Mental disorders Narcolepsy Neurology Neurology • Original Article Neurotrophin 1 Neurotrophin 2 Otorhinolaryngology Pediatrics Pneumology/Respiratory System Regression analysis Sleep Sleep disorders |
| title | Comorbid psychiatric disorders among patients with narcolepsy |
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