Analysis of miRNA–mRNA network reveals miR-140-5p as a suppressor of breast cancer glycolysis via targeting GLUT1

Aerobic glycolysis is characteristic of breast cancer. Comprehensive expression profiles of key proteins, their prognosis and detailed relationships between miRNAs and mRNAs remain unclear. Oncomine database, Kaplan–Meier overall survival and miRNA–mRNA network analysis were performed. A key miRNA w...

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Veröffentlicht in:	Epigenomics 2019-07, Vol.11 (9), p.1021-1036
Hauptverfasser:	He, Yunjie, Deng, Fei, Zhao, Shujie, Zhong, Shanliang, Zhao, Jianhua, Wang, Dandan, Chen, Xiu, Zhang, Jian, Hou, Junchen, Zhang, Wei, Ding, Li, Tang, Jinhai, Zhou, Zuomin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Breast cancer breast carcinoma Breast Neoplasms - diagnosis Breast Neoplasms - genetics Cancer therapies Cell growth Cell Line, Tumor Cell Proliferation Down-Regulation expression Female Gene expression Glucose Transporter Type 1 - genetics GLUT1 Glyceraldehyde-3-phosphate dehydrogenase Glycolysis Glycolysis - genetics Humans Hypoxia Leukemia Medical prognosis Metabolism Metabolites MicroRNAs MicroRNAs - genetics miR-140-5p miRNA miRNA–mRNA network mRNA Network analysis Penicillin Phosphorylation Plasmids Prognosis proliferation Proteins RNA, Messenger - genetics SLC2A1 Survival analysis Tumorigenesis
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