Fasting Reduces Intestinal Radiotoxicity, Enabling Dose-Escalated Radiation Therapy for Pancreatic Cancer

Chemotherapy combined with radiation therapy is the most commonly used approach for treating locally advanced pancreatic cancer. The use of curative doses of radiation in this disease setting is constrained because of the close proximity of the head of the pancreas to the duodenum. The purpose of th...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2019-11, Vol.105 (3), p.537-547
Hauptverfasser:	de la Cruz Bonilla, Marimar, Stemler, Kristina M., Jeter-Jones, Sabrina, Fujimoto, Tara N., Molkentine, Jessica, Asencio Torres, Gabriela M., Zhang, Xiaomei, Broaddus, Russell R., Taniguchi, Cullen M., Piwnica-Worms, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen - radiation effects Animals Apoptosis Cell Line, Tumor DNA Breaks, Double-Stranded Duodenum - radiation effects Fasting Female Histones - metabolism Intestine, Small - cytology Intestine, Small - radiation effects Male Maximum Tolerated Dose Mice Mice, Inbred C57BL Organ Sparing Treatments Organs at Risk - radiation effects Pancreatic Neoplasms - mortality Pancreatic Neoplasms - radiotherapy Proof of Concept Study Radiation Injuries - mortality Radiation Injuries - prevention & control Radiation Tolerance Radiotherapy Dosage Random Allocation Regeneration Stem Cells - physiology Stem Cells - radiation effects Time Factors Tumor Stem Cell Assay - methods
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