Long‐term leukoencephalopathy and neurocognitive functioning in childhood sarcoma patients treated with high‐dose intravenous chemotherapy

Purpose Knowledge is limited regarding the prevalence and persistence of chemotherapy‐induced leukoencephalopathy in childhood sarcoma patients. This study explored the presence, clinical relevance, and potential risk factors of leukoencephalopathy in childhood bone and soft tissue sarcoma survivors...

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Veröffentlicht in:	Pediatric blood & cancer 2019-10, Vol.66 (10), p.e27893-n/a
Hauptverfasser:	Sleurs, Charlotte, Lemiere, Jurgen, Radwan, Ahmed, Verly, Marjolein, Elens, Iris, Renard, Marleen, Jacobs, Sandra, Sunaert, Stefan, Deprez, Sabine, Uyttebroeck, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adolescent Adult Alkylating agents Alkylation Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Cancer Survivors Chemotherapy Childhood childhood sarcoma Children Cognition Cognition Disorders - chemically induced Cross-Sectional Studies Demyelination Diffusion rate Female genetics Hematology high‐dose chemotherapy Humans Information processing Intravenous administration Lesions Leukoencephalopathies - chemically induced Leukoencephalopathy Magnetic resonance imaging Male Memory Methotrexate Myelin neurocognition NMR Nuclear magnetic resonance Oncology Pediatrics Quality of life Risk factors Sarcoma Sarcoma - drug therapy Short term memory Soft tissue sarcoma Young Adult
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