Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts

Blood samples, bone marrow, tumours and metastases where possible were collected from SCID mice bearing orthotopic xenografts of the triple-negative MDA-MB-468 cell line or a transplantable ER-positive patient derived xenograft (ED-03), and assessed using human-specific, tandem-nested RT-qPCR for ma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical & experimental metastasis 2019-08, Vol.36 (4), p.393-409
Hauptverfasser:	Tachtsidis, Anthony, Le, Anh Viet-Phuong, Blick, Tony, Gunasinghe, Devika, De Sousa, Emma, Waltham, Mark, Dobrovic, Alex, Thompson, Erik W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blood circulation BNIP3 protein Bone cancer Bone marrow Bone tumors Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Cell Line, Tumor E-cadherin Epidermal growth factor receptors Epithelial-Mesenchymal Transition Female Hematology Heterogeneity Humans Hypoxia ILK protein Markers Mesenchyme Metabolism Metastases Mice, SCID Neoplasm Micrometastasis Neoplasm Transplantation Neoplasm, Residual Neoplastic Cells, Circulating - pathology Notch1 protein Oncology Phenotypes Phenotypic plasticity Plastic properties Plasticity Research Paper Ribonucleic acid RNA RNA, Messenger - analysis Snail protein Stem cells Surgical Oncology Transplantation, Heterologous Tumors Xenografts Xenotransplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!