Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents

A series of novel fluoroquinolone-Safirinium dye hybrids was synthesized by means of tandem Mannich-electrophilic amination reactions from profluorophoric isoxazolones and antibiotics bearing a secondary amino group at position 7 of the quinoline ring. The obtained fluorescent spiro fused conjugates...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-10, Vol.179, p.576-590
Hauptverfasser:	Fedorowicz, Joanna, Sączewski, Jarosław, Konopacka, Agnieszka, Waleron, Krzysztof, Lejnowski, Dawid, Ciura, Krzesimir, Tomašič, Tihomir, Skok, Žiga, Savijoki, Kirsi, Morawska, Małgorzata, Gilbert-Girard, Shella, Fallarero, Adyary
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial activity Drug synthesis Enzyme inhibition Hybrid compounds Molecular docking Quinolone
Online-Zugang:	Volltext
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