Monosaccharide Analogues of Anticancer Peptide R‑Lycosin-I: Role of Monosaccharide Conjugation in Complexation and the Potential of Lung Cancer Targeting and Therapy

Glycoconjugation is a promising modification strategy for the optimization of peptide drugs. In this study, five different monosaccharide derivatives (7a–e) were covalently linked to the N-terminal of R-lycosin-I, which yielded five glycopeptides (8a–e). They demonstrated increased or reduced cytoto...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2019-09, Vol.62 (17), p.7857-7873
Hauptverfasser:	Zhang, Peng, Ma, Jing, Zhang, Qianqian, Jian, Shandong, Sun, Xiaoliang, Liu, Bobo, Nie, Liqin, Liu, Meiyan, Liang, Songping, Zeng, Youlin, Liu, Zhonghua
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!