Direct effects of poly(ε-caprolactone) lipid-core nanocapsules on human immune cells

Poly(ε-caprolactone) lipid-core nanocapsules (LNCs) are efficient drug carriers and drug-free LNCs display therapeutic effects, inhibiting tumor growth and neutrophil activities. Herein, we investigated the direct actions of LNCs on human immune cells, to guide their therapeutic application. LNC’s u...

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Veröffentlicht in:	Nanomedicine (London, England) England), 2019-06, Vol.14 (11), p.1429-1442
Hauptverfasser:	Sandri, Silvana, Hebeda, Cristina Bichels, Loiola, Rodrigo Azevedo, Calgaroto, Selma, Uchiyama, Mayara Klimuk, Araki, Koiti, Frank, Luiza Abrahão, Paese, Karina, Guterres, Silvia Stanisçuaski, Pohlmann, Adriana Raffin, Farsky, Sandra Helena Poliselli
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Cells - drug effects Cancer therapies Cell adhesion & migration Cell cycle cell migration Cell Movement Cell Proliferation Cell Survival Cytokines Cytokines - metabolism cytokines release Drug Carriers - chemistry Drug Carriers - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation Hexoses - chemistry Human Umbilical Vein Endothelial Cells - drug effects Humans Immune system immunosuppression Kinases Lipids Lipids - chemistry MAPK signaling Melanoma Nanocapsules - chemistry Nanoparticles Neutrophils peripheral blood mononuclear cells Polyesters - chemistry polymorphonuclear cells Signal Transduction
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