Rapid determination of antibiotic residues in cereals by liquid chromatography triple mass spectrometry
Antibiotics may be present in agricultural soils through the application of organic amendments as fertilizers or by irrigation of fields with recycled water. As a result of these agricultural practices, antibiotics in soil can lead to their uptake by plants, entering in this way the food chain. Stud...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2019-09, Vol.411 (23), p.6129-6139 |
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| creator | Albero, Beatriz Tadeo, José Luis Miguel, Esther Pérez, Rosa Ana |
| description | Antibiotics may be present in agricultural soils through the application of organic amendments as fertilizers or by irrigation of fields with recycled water. As a result of these agricultural practices, antibiotics in soil can lead to their uptake by plants, entering in this way the food chain. Studies on the levels of antibiotics in cereal samples are scarce in the available literature. In this work, an analytical method was developed for the determination of 19 antibiotics (fluoroquinolones, sulfonamides, tetracyclines, and lincosamides) in four types of cereal grains (wheat, barley, rice, and oat). Ultrasound-assisted matrix solid-phase dispersion was selected as extraction technique with recoveries of target analytes ranging from 73 to 127% for the four cereals analyzed. Limits of quantification obtained ranged from 0.8 to 5.8 ng g
−1
. Compared with methods described for the analysis of antibiotics in cereals, the developed method uses a lower volume of extraction solvent and very good recoveries were obtained for all compounds. The validated method was applied to the analysis of different types of cereals samples, harvested from agricultural fields or purchased from local supermarkets. The analysis of the five cereal samples grown in fields with 3 years of consecutive organic amendments revealed that none of the nineteen antibiotics selected were found in any sample. Eleven commercial samples of cereals of different types and presentations were analyzed and enrofloxacin was detected in one rice sample; the presence of enrofloxacin in cereals or its incorporation into crops from soil or water not previously reported.
Graphical abstract |
| doi_str_mv | 10.1007/s00216-019-02003-w |
| format | Article |
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−1
. Compared with methods described for the analysis of antibiotics in cereals, the developed method uses a lower volume of extraction solvent and very good recoveries were obtained for all compounds. The validated method was applied to the analysis of different types of cereals samples, harvested from agricultural fields or purchased from local supermarkets. The analysis of the five cereal samples grown in fields with 3 years of consecutive organic amendments revealed that none of the nineteen antibiotics selected were found in any sample. Eleven commercial samples of cereals of different types and presentations were analyzed and enrofloxacin was detected in one rice sample; the presence of enrofloxacin in cereals or its incorporation into crops from soil or water not previously reported.
Graphical abstract </description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-019-02003-w</identifier><identifier>PMID: 31278554</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Agricultural land ; Agricultural practices ; Agrochemicals ; Analysis ; Analytical Chemistry ; Antibiotics ; Barley ; Biochemistry ; Cereals ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Enrofloxacin ; Ethylenediaminetetraacetic acid ; Fertilizers ; Fluoroquinolones ; Food chains ; Food Science ; Grain ; Laboratory Medicine ; Lincosamides ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Monitoring/Environmental Analysis ; Oryza ; Research Paper ; Rice ; Soil water ; Solid phases ; Sulfonamides ; Supermarkets ; Tetracycline ; Tetracyclines ; Ultrasound ; Water reuse ; Wheat</subject><ispartof>Analytical and bioanalytical chemistry, 2019-09, Vol.411 (23), p.6129-6139</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Analytical and Bioanalytical Chemistry is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-8371e539eecc003543e144f8bef874f169cd9364ee31683a8c67b2b7abdca2753</citedby><cites>FETCH-LOGICAL-c442t-8371e539eecc003543e144f8bef874f169cd9364ee31683a8c67b2b7abdca2753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-019-02003-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-019-02003-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31278554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albero, Beatriz</creatorcontrib><creatorcontrib>Tadeo, José Luis</creatorcontrib><creatorcontrib>Miguel, Esther</creatorcontrib><creatorcontrib>Pérez, Rosa Ana</creatorcontrib><title>Rapid determination of antibiotic residues in cereals by liquid chromatography triple mass spectrometry</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Antibiotics may be present in agricultural soils through the application of organic amendments as fertilizers or by irrigation of fields with recycled water. As a result of these agricultural practices, antibiotics in soil can lead to their uptake by plants, entering in this way the food chain. Studies on the levels of antibiotics in cereal samples are scarce in the available literature. In this work, an analytical method was developed for the determination of 19 antibiotics (fluoroquinolones, sulfonamides, tetracyclines, and lincosamides) in four types of cereal grains (wheat, barley, rice, and oat). Ultrasound-assisted matrix solid-phase dispersion was selected as extraction technique with recoveries of target analytes ranging from 73 to 127% for the four cereals analyzed. Limits of quantification obtained ranged from 0.8 to 5.8 ng g
−1
. Compared with methods described for the analysis of antibiotics in cereals, the developed method uses a lower volume of extraction solvent and very good recoveries were obtained for all compounds. The validated method was applied to the analysis of different types of cereals samples, harvested from agricultural fields or purchased from local supermarkets. The analysis of the five cereal samples grown in fields with 3 years of consecutive organic amendments revealed that none of the nineteen antibiotics selected were found in any sample. Eleven commercial samples of cereals of different types and presentations were analyzed and enrofloxacin was detected in one rice sample; the presence of enrofloxacin in cereals or its incorporation into crops from soil or water not previously reported.
Graphical abstract </description><subject>Agricultural land</subject><subject>Agricultural practices</subject><subject>Agrochemicals</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Antibiotics</subject><subject>Barley</subject><subject>Biochemistry</subject><subject>Cereals</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Enrofloxacin</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fertilizers</subject><subject>Fluoroquinolones</subject><subject>Food chains</subject><subject>Food Science</subject><subject>Grain</subject><subject>Laboratory Medicine</subject><subject>Lincosamides</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Monitoring/Environmental Analysis</subject><subject>Oryza</subject><subject>Research Paper</subject><subject>Rice</subject><subject>Soil water</subject><subject>Solid phases</subject><subject>Sulfonamides</subject><subject>Supermarkets</subject><subject>Tetracycline</subject><subject>Tetracyclines</subject><subject>Ultrasound</subject><subject>Water 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chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>411</volume><issue>23</issue><spage>6129</spage><epage>6139</epage><pages>6129-6139</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Antibiotics may be present in agricultural soils through the application of organic amendments as fertilizers or by irrigation of fields with recycled water. As a result of these agricultural practices, antibiotics in soil can lead to their uptake by plants, entering in this way the food chain. Studies on the levels of antibiotics in cereal samples are scarce in the available literature. In this work, an analytical method was developed for the determination of 19 antibiotics (fluoroquinolones, sulfonamides, tetracyclines, and lincosamides) in four types of cereal grains (wheat, barley, rice, and oat). Ultrasound-assisted matrix solid-phase dispersion was selected as extraction technique with recoveries of target analytes ranging from 73 to 127% for the four cereals analyzed. Limits of quantification obtained ranged from 0.8 to 5.8 ng g
−1
. Compared with methods described for the analysis of antibiotics in cereals, the developed method uses a lower volume of extraction solvent and very good recoveries were obtained for all compounds. The validated method was applied to the analysis of different types of cereals samples, harvested from agricultural fields or purchased from local supermarkets. The analysis of the five cereal samples grown in fields with 3 years of consecutive organic amendments revealed that none of the nineteen antibiotics selected were found in any sample. Eleven commercial samples of cereals of different types and presentations were analyzed and enrofloxacin was detected in one rice sample; the presence of enrofloxacin in cereals or its incorporation into crops from soil or water not previously reported.
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| subjects | Agricultural land Agricultural practices Agrochemicals Analysis Analytical Chemistry Antibiotics Barley Biochemistry Cereals Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Enrofloxacin Ethylenediaminetetraacetic acid Fertilizers Fluoroquinolones Food chains Food Science Grain Laboratory Medicine Lincosamides Liquid chromatography Mass spectrometry Mass spectroscopy Monitoring/Environmental Analysis Oryza Research Paper Rice Soil water Solid phases Sulfonamides Supermarkets Tetracycline Tetracyclines Ultrasound Water reuse Wheat |
| title | Rapid determination of antibiotic residues in cereals by liquid chromatography triple mass spectrometry |
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