Brivanib, a multitargeted small‐molecule tyrosine kinase inhibitor, suppresses laser‐induced CNV in a mouse model of neovascular AMD

In age‐related macular degeneration (AMD), choroidal neovascularization (CNV), a major pathologic feature of neovascular AMD (nAMD), affects 10% of patients, potentially causing serious complications, including vision loss. Vascular endothelial growth factor receptor 2 (VEGFR2) and fibroblast growth...

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Veröffentlicht in:	Journal of cellular physiology 2020-02, Vol.235 (2), p.1259-1273
Hauptverfasser:	Li, Lele, Zhu, Manhui, Wu, Wenli, Qin, Bai, Gu, Jiayi, Tu, Yuanyuan, Chen, Jianing, Liu, Dong, Shi, Yunwei, Liu, Xiaojuan, Sang, Aimin, Ding, Dongmei
Format:	Artikel
Sprache:	eng
Schlagworte:	age‐related macular degeneration Angiogenesis Cell proliferation choroidal neovascularization Embryos Endothelial cells Enzyme inhibitors Eye diseases Fibroblast growth factor receptor 1 Growth factors Inhibitors Injection Kinases Leakage Macular degeneration Microvasculature Pathogenesis Phosphorylation Protein-tyrosine kinase receptors receptor tyrosine kinase inhibitor Retina Toxicity Tyrosine Vascular endothelial growth factor Vascular endothelial growth factor receptor 2 Vascularization Zebrafish
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