Paternal age contribution to brain white matter aberrations in autism spectrum disorder
Aim Although advanced parental age holds an increased risk for autism spectrum disorder (ASD), its role as a potential risk factor for an atypical white matter development underlying the pathophysiology of ASD has not yet been investigated. The current study was aimed to detect white matter disparit...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2019-10, Vol.73 (10), p.649-659 |
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| creator | Yassin, Walid Kojima, Masaki Owada, Keiho Kuwabara, Hitoshi Gonoi, Wataru Aoki, Yuta Takao, Hidemasa Natsubori, Tatsunobu Iwashiro, Norichika Kasai, Kiyoto Kano, Yukiko Abe, Osamu Yamasue, Hidenori |
| description | Aim
Although advanced parental age holds an increased risk for autism spectrum disorder (ASD), its role as a potential risk factor for an atypical white matter development underlying the pathophysiology of ASD has not yet been investigated. The current study was aimed to detect white matter disparities in ASD, and further investigate the relationship of paternal and maternal age at birth with such disparities.
Methods
Thirty‐nine adult males with high‐functioning ASD and 37 typically developing (TD) males were analyzed in the study. The FMRIB Software Library and tract‐based spatial statistics were utilized to process and analyze the diffusion tensor imaging data.
Results
Subjects with ASD exhibited significantly higher mean diffusivity (MD) and radial diffusivity (RD) in white matter fibers, including the association (inferior fronto‐occipital fasciculus, right inferior longitudinal fasciculus, superior longitudinal fasciculi, uncinate fasciculus, and cingulum), commissural (forceps minor), and projection tracts (anterior thalamic radiation and right corticospinal tract) compared to TD subjects (Padjusted |
| doi_str_mv | 10.1111/pcn.12909 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2252242967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2301766459</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4789-ca1e2aa846d4116f7b34166ee9fd7f3c37c27e88d93c9cceef4420a2442ff0cb3</originalsourceid><addsrcrecordid>eNp10MtKAzEUBuAgiq3VhS8gATe6mDYnSTOTpRRvULQLxeWQyZzRKXOpyQylb29qqwvBLE4C-fjh_IScAxtDOJOVbcbANdMHZAhSsggS0IfhLbiIQIAakBPvl4wxIRQck4EAHgOXekjeFqZD15iKmnektm06V2Z9V7YN7VqaOVM2dP1Rdkhr0wVJTYbOmS3wNPyZYH1N_Qpt5_qa5qVvXY7ulBwVpvJ4tr9H5PXu9mX2EM2f7x9nN_PIyjjRkTWA3JhEqlwCqCLOhASlEHWRx4WwIrY8xiTJtbDaWsRCSs4MD7MomM3EiFztcleu_ezRd2ldeotVZRpse59yPuVccq3iQC__0GXbb1cPSjCIlZJTHdT1TlnXeu-wSFeurI3bpMDSbdtpaDv9bjvYi31in9WY_8qfegOY7MC6rHDzf1K6mD3tIr8AgLmJsA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2301766459</pqid></control><display><type>article</type><title>Paternal age contribution to brain white matter aberrations in autism spectrum disorder</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Open Access Titles of Japan</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Yassin, Walid ; Kojima, Masaki ; Owada, Keiho ; Kuwabara, Hitoshi ; Gonoi, Wataru ; Aoki, Yuta ; Takao, Hidemasa ; Natsubori, Tatsunobu ; Iwashiro, Norichika ; Kasai, Kiyoto ; Kano, Yukiko ; Abe, Osamu ; Yamasue, Hidenori</creator><creatorcontrib>Yassin, Walid ; Kojima, Masaki ; Owada, Keiho ; Kuwabara, Hitoshi ; Gonoi, Wataru ; Aoki, Yuta ; Takao, Hidemasa ; Natsubori, Tatsunobu ; Iwashiro, Norichika ; Kasai, Kiyoto ; Kano, Yukiko ; Abe, Osamu ; Yamasue, Hidenori</creatorcontrib><description>Aim
Although advanced parental age holds an increased risk for autism spectrum disorder (ASD), its role as a potential risk factor for an atypical white matter development underlying the pathophysiology of ASD has not yet been investigated. The current study was aimed to detect white matter disparities in ASD, and further investigate the relationship of paternal and maternal age at birth with such disparities.
Methods
Thirty‐nine adult males with high‐functioning ASD and 37 typically developing (TD) males were analyzed in the study. The FMRIB Software Library and tract‐based spatial statistics were utilized to process and analyze the diffusion tensor imaging data.
Results
Subjects with ASD exhibited significantly higher mean diffusivity (MD) and radial diffusivity (RD) in white matter fibers, including the association (inferior fronto‐occipital fasciculus, right inferior longitudinal fasciculus, superior longitudinal fasciculi, uncinate fasciculus, and cingulum), commissural (forceps minor), and projection tracts (anterior thalamic radiation and right corticospinal tract) compared to TD subjects (Padjusted < 0.05). No differences were seen in either fractional anisotropy or axial diffusivity. Linear regression analyses assessing the relationship between parental ages and the white matter aberrations revealed a positive correlation between paternal age (PA), but not maternal age, and both MD and RD in the affected fibers (Padjusted < 0.05). Multiple regression showed that only PA was a predictor of both MD and RD.
Conclusion
Our findings suggest that PA contributes to the white matter disparities seen in individuals with ASD compared to TD subjects.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/pcn.12909</identifier><identifier>PMID: 31271249</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Adult ; Age ; Anisotropy ; Attention deficit hyperactivity disorder ; Autism ; autism spectrum disorder ; Autism Spectrum Disorder - diagnostic imaging ; Autism Spectrum Disorder - pathology ; Cingulum ; Diffusion Tensor Imaging ; Female ; Humans ; Magnetic resonance imaging ; Male ; Maternal Age ; Neuroimaging ; Paternal Age ; Pyramidal tracts ; Risk factors ; Substantia alba ; Thalamus ; white matter ; White Matter - diagnostic imaging ; White Matter - pathology ; Young Adult</subject><ispartof>Psychiatry and clinical neurosciences, 2019-10, Vol.73 (10), p.649-659</ispartof><rights>2019 The Authors. Psychiatry and Clinical Neurosciences © 2019 Japanese Society of Psychiatry and Neurology</rights><rights>2019 The Authors. Psychiatry and Clinical Neurosciences © 2019 Japanese Society of Psychiatry and Neurology.</rights><rights>2019 The Author. Psychiatry and Clinical Neurosciences © 2019 Japanese Society of Psychiatry and Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4789-ca1e2aa846d4116f7b34166ee9fd7f3c37c27e88d93c9cceef4420a2442ff0cb3</citedby><cites>FETCH-LOGICAL-c4789-ca1e2aa846d4116f7b34166ee9fd7f3c37c27e88d93c9cceef4420a2442ff0cb3</cites><orcidid>0000-0002-2748-6317 ; 0000-0002-4443-4535</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcn.12909$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcn.12909$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31271249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yassin, Walid</creatorcontrib><creatorcontrib>Kojima, Masaki</creatorcontrib><creatorcontrib>Owada, Keiho</creatorcontrib><creatorcontrib>Kuwabara, Hitoshi</creatorcontrib><creatorcontrib>Gonoi, Wataru</creatorcontrib><creatorcontrib>Aoki, Yuta</creatorcontrib><creatorcontrib>Takao, Hidemasa</creatorcontrib><creatorcontrib>Natsubori, Tatsunobu</creatorcontrib><creatorcontrib>Iwashiro, Norichika</creatorcontrib><creatorcontrib>Kasai, Kiyoto</creatorcontrib><creatorcontrib>Kano, Yukiko</creatorcontrib><creatorcontrib>Abe, Osamu</creatorcontrib><creatorcontrib>Yamasue, Hidenori</creatorcontrib><title>Paternal age contribution to brain white matter aberrations in autism spectrum disorder</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>Aim
Although advanced parental age holds an increased risk for autism spectrum disorder (ASD), its role as a potential risk factor for an atypical white matter development underlying the pathophysiology of ASD has not yet been investigated. The current study was aimed to detect white matter disparities in ASD, and further investigate the relationship of paternal and maternal age at birth with such disparities.
Methods
Thirty‐nine adult males with high‐functioning ASD and 37 typically developing (TD) males were analyzed in the study. The FMRIB Software Library and tract‐based spatial statistics were utilized to process and analyze the diffusion tensor imaging data.
Results
Subjects with ASD exhibited significantly higher mean diffusivity (MD) and radial diffusivity (RD) in white matter fibers, including the association (inferior fronto‐occipital fasciculus, right inferior longitudinal fasciculus, superior longitudinal fasciculi, uncinate fasciculus, and cingulum), commissural (forceps minor), and projection tracts (anterior thalamic radiation and right corticospinal tract) compared to TD subjects (Padjusted < 0.05). No differences were seen in either fractional anisotropy or axial diffusivity. Linear regression analyses assessing the relationship between parental ages and the white matter aberrations revealed a positive correlation between paternal age (PA), but not maternal age, and both MD and RD in the affected fibers (Padjusted < 0.05). Multiple regression showed that only PA was a predictor of both MD and RD.
Conclusion
Our findings suggest that PA contributes to the white matter disparities seen in individuals with ASD compared to TD subjects.</description><subject>Adult</subject><subject>Age</subject><subject>Anisotropy</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>autism spectrum disorder</subject><subject>Autism Spectrum Disorder - diagnostic imaging</subject><subject>Autism Spectrum Disorder - pathology</subject><subject>Cingulum</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Neuroimaging</subject><subject>Paternal Age</subject><subject>Pyramidal tracts</subject><subject>Risk factors</subject><subject>Substantia alba</subject><subject>Thalamus</subject><subject>white matter</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><subject>Young Adult</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKAzEUBuAgiq3VhS8gATe6mDYnSTOTpRRvULQLxeWQyZzRKXOpyQylb29qqwvBLE4C-fjh_IScAxtDOJOVbcbANdMHZAhSsggS0IfhLbiIQIAakBPvl4wxIRQck4EAHgOXekjeFqZD15iKmnektm06V2Z9V7YN7VqaOVM2dP1Rdkhr0wVJTYbOmS3wNPyZYH1N_Qpt5_qa5qVvXY7ulBwVpvJ4tr9H5PXu9mX2EM2f7x9nN_PIyjjRkTWA3JhEqlwCqCLOhASlEHWRx4WwIrY8xiTJtbDaWsRCSs4MD7MomM3EiFztcleu_ezRd2ldeotVZRpse59yPuVccq3iQC__0GXbb1cPSjCIlZJTHdT1TlnXeu-wSFeurI3bpMDSbdtpaDv9bjvYi31in9WY_8qfegOY7MC6rHDzf1K6mD3tIr8AgLmJsA</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Yassin, Walid</creator><creator>Kojima, Masaki</creator><creator>Owada, Keiho</creator><creator>Kuwabara, Hitoshi</creator><creator>Gonoi, Wataru</creator><creator>Aoki, Yuta</creator><creator>Takao, Hidemasa</creator><creator>Natsubori, Tatsunobu</creator><creator>Iwashiro, Norichika</creator><creator>Kasai, Kiyoto</creator><creator>Kano, Yukiko</creator><creator>Abe, Osamu</creator><creator>Yamasue, Hidenori</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2748-6317</orcidid><orcidid>https://orcid.org/0000-0002-4443-4535</orcidid></search><sort><creationdate>201910</creationdate><title>Paternal age contribution to brain white matter aberrations in autism spectrum disorder</title><author>Yassin, Walid ; Kojima, Masaki ; Owada, Keiho ; Kuwabara, Hitoshi ; Gonoi, Wataru ; Aoki, Yuta ; Takao, Hidemasa ; Natsubori, Tatsunobu ; Iwashiro, Norichika ; Kasai, Kiyoto ; Kano, Yukiko ; Abe, Osamu ; Yamasue, Hidenori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4789-ca1e2aa846d4116f7b34166ee9fd7f3c37c27e88d93c9cceef4420a2442ff0cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Anisotropy</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Autism</topic><topic>autism spectrum disorder</topic><topic>Autism Spectrum Disorder - diagnostic imaging</topic><topic>Autism Spectrum Disorder - pathology</topic><topic>Cingulum</topic><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Neuroimaging</topic><topic>Paternal Age</topic><topic>Pyramidal tracts</topic><topic>Risk factors</topic><topic>Substantia alba</topic><topic>Thalamus</topic><topic>white matter</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yassin, Walid</creatorcontrib><creatorcontrib>Kojima, Masaki</creatorcontrib><creatorcontrib>Owada, Keiho</creatorcontrib><creatorcontrib>Kuwabara, Hitoshi</creatorcontrib><creatorcontrib>Gonoi, Wataru</creatorcontrib><creatorcontrib>Aoki, Yuta</creatorcontrib><creatorcontrib>Takao, Hidemasa</creatorcontrib><creatorcontrib>Natsubori, Tatsunobu</creatorcontrib><creatorcontrib>Iwashiro, Norichika</creatorcontrib><creatorcontrib>Kasai, Kiyoto</creatorcontrib><creatorcontrib>Kano, Yukiko</creatorcontrib><creatorcontrib>Abe, Osamu</creatorcontrib><creatorcontrib>Yamasue, Hidenori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yassin, Walid</au><au>Kojima, Masaki</au><au>Owada, Keiho</au><au>Kuwabara, Hitoshi</au><au>Gonoi, Wataru</au><au>Aoki, Yuta</au><au>Takao, Hidemasa</au><au>Natsubori, Tatsunobu</au><au>Iwashiro, Norichika</au><au>Kasai, Kiyoto</au><au>Kano, Yukiko</au><au>Abe, Osamu</au><au>Yamasue, Hidenori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paternal age contribution to brain white matter aberrations in autism spectrum disorder</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2019-10</date><risdate>2019</risdate><volume>73</volume><issue>10</issue><spage>649</spage><epage>659</epage><pages>649-659</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>Aim
Although advanced parental age holds an increased risk for autism spectrum disorder (ASD), its role as a potential risk factor for an atypical white matter development underlying the pathophysiology of ASD has not yet been investigated. The current study was aimed to detect white matter disparities in ASD, and further investigate the relationship of paternal and maternal age at birth with such disparities.
Methods
Thirty‐nine adult males with high‐functioning ASD and 37 typically developing (TD) males were analyzed in the study. The FMRIB Software Library and tract‐based spatial statistics were utilized to process and analyze the diffusion tensor imaging data.
Results
Subjects with ASD exhibited significantly higher mean diffusivity (MD) and radial diffusivity (RD) in white matter fibers, including the association (inferior fronto‐occipital fasciculus, right inferior longitudinal fasciculus, superior longitudinal fasciculi, uncinate fasciculus, and cingulum), commissural (forceps minor), and projection tracts (anterior thalamic radiation and right corticospinal tract) compared to TD subjects (Padjusted < 0.05). No differences were seen in either fractional anisotropy or axial diffusivity. Linear regression analyses assessing the relationship between parental ages and the white matter aberrations revealed a positive correlation between paternal age (PA), but not maternal age, and both MD and RD in the affected fibers (Padjusted < 0.05). Multiple regression showed that only PA was a predictor of both MD and RD.
Conclusion
Our findings suggest that PA contributes to the white matter disparities seen in individuals with ASD compared to TD subjects.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>31271249</pmid><doi>10.1111/pcn.12909</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2748-6317</orcidid><orcidid>https://orcid.org/0000-0002-4443-4535</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychiatry and clinical neurosciences, 2019-10, Vol.73 (10), p.649-659 |
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| source | MEDLINE; Wiley Free Content; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adult Age Anisotropy Attention deficit hyperactivity disorder Autism autism spectrum disorder Autism Spectrum Disorder - diagnostic imaging Autism Spectrum Disorder - pathology Cingulum Diffusion Tensor Imaging Female Humans Magnetic resonance imaging Male Maternal Age Neuroimaging Paternal Age Pyramidal tracts Risk factors Substantia alba Thalamus white matter White Matter - diagnostic imaging White Matter - pathology Young Adult |
| title | Paternal age contribution to brain white matter aberrations in autism spectrum disorder |
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