DPP-4 inhibitor improves learning and memory deficits and AD-like neurodegeneration by modulating the GLP-1 signaling

Glucagon-like peptide-1 (GLP-1) signaling in the brain plays an important role in the regulation of glucose metabolism, which is impaired in Alzheimer's disease (AD). Here, we detected the GLP-1 and GLP-1 receptor (GLP-1R) in AD human brain and APP/PS1/Tau transgenic (3xTg) mice brain, finding...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Neuropharmacology 2019-10, Vol.157, p.107668-107668, Article 107668
Hauptverfasser:	Chen, Shuyi, Zhou, Mei, Sun, Jie, Guo, Ai, Fernando, Roger Lakmal, Chen, Yanlin, Peng, Peng, Zhao, Gang, Deng, Yanqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Dipeptidyl peptidase-4 inhibitor GLP-1 signaling Neurodegeneration NFs Tau
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!