Rhodium(III)-Catalyzed C–H Activation: Ligand-Controlled Regioselective Synthesis of 4‑Methyl-Substituted Dihydroisoquinolones

Rh-catalyzed C–H functionalization of O-pivaloyl benzhydroxamic acids with propene gas provides access to 4-methyl-substituted dihydroisoquinolones. Good to excellent levels of regioselectivity are achieved using [CptRhCl2]2 as a precatalyst under optimized conditions. Thorough examination of aryl/h...

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Veröffentlicht in:	Organic letters 2019-07, Vol.21 (14), p.5689-5693
Hauptverfasser:	Barber, Joyann S, Scales, Stephanie, Tran-Dubé, Michelle, Wang, Fen, Sach, Neal W, Bernier, Louise, Collins, Michael R, Zhu, JinJiang, McAlpine, Indrawan J, Patman, Ryan L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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