Markers of Collagen Formation and Degradation Reflect Renal Function and Predict Adverse Outcomes in Patients With Type 1 Diabetes

Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, a biomarker of collagen type VI formation, and C3M, a biomark...

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Veröffentlicht in:	Diabetes care 2019-09, Vol.42 (9), p.1760-1768
Hauptverfasser:	Pilemann-Lyberg, Sascha, Rasmussen, Daniel Guldager Kring, Hansen, Tine Willum, Tofte, Nete, Winther, Signe Abitz, Holm Nielsen, Signe, Theilade, Simone, Karsdal, Morten Asser, Genovese, Federica, Rossing, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers Biomarkers - blood Cardiovascular diseases Collagen Collagen (type I) Collagen (type III) Collagen Type III - blood Collagen Type VI - blood Degradation Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - mortality Diabetic Cardiomyopathies - etiology Diabetic Cardiomyopathies - mortality Diabetic Nephropathies - etiology Diabetic Nephropathies - mortality End-stage renal disease Enzyme-linked immunosorbent assay Epidermal growth factor receptors Female Glomerular Filtration Rate Hazards Health risk assessment Health risks Heart Heart diseases Heart failure Heart Failure - etiology Heart Failure - mortality Humans Kidney - physiopathology Kidney diseases Kidney Failure, Chronic - etiology Kidney Failure, Chronic - mortality Male Medical prognosis Middle Aged Mortality Procollagen - blood Prognosis Proportional Hazards Models Renal function Research design Risk Risk Factors Statistical models Urine
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