Discovery of 4‑Aminoquinoline-3-carboxamide Derivatives as Potent Reversible Bruton’s Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis

A structure-hopping strategy was applied to discover a series of novel 4-aminoquinoline-3-carboxamide derivatives as potent, reversible BTK inhibitors. Compared to the previously described cinnoline scaffold compounds, the 4-aminoquinoline analogues showed significantly improved drug-like properties...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-07, Vol.62 (14), p.6561-6574
Hauptverfasser:	Yao, Xia, Sun, Xiuyun, Jin, Shuyu, Yang, Ling, Xu, Hongjiang, Rao, Yu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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