Gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol addiction: a serious health threat
[...]its reputation of a rape drug (4, 5). The development of hyphenated analytical techniques (17, 18) such as ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) is therefore crucial if we want to be able to...
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| Veröffentlicht in: | Arhiv za higijenu rada i toksikologiju 2019-06, Vol.70 (2), p.149-150 |
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| container_title | Arhiv za higijenu rada i toksikologiju |
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| creator | Beck, Renata Matanović, Suzana Mimica Zibar, Lada |
| description | [...]its reputation of a rape drug (4, 5). The development of hyphenated analytical techniques (17, 18) such as ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) is therefore crucial if we want to be able to identify GHB and its precursors in conventional and unconventional biological matrices, bearing in mind the current proposed cut-offs to distinguish between endogenous and exogenous GHB (22). [...]we urge the scientific community investigating GHB to focus on new alternative metabolites, such as the carboxylic glucuronated metabolite, that may provide a longer detection window than the current ones. Gentili S, Mortali C, Mastrobattista L, Berretta P, Zaami S. Determination of different recreational drugs in sweat by headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME GC/MS): Application to drugged drivers. |
| doi_str_mv | 10.2478/aiht-2019-70-3295 |
| format | Article |
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The development of hyphenated analytical techniques (17, 18) such as ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) is therefore crucial if we want to be able to identify GHB and its precursors in conventional and unconventional biological matrices, bearing in mind the current proposed cut-offs to distinguish between endogenous and exogenous GHB (22). [...]we urge the scientific community investigating GHB to focus on new alternative metabolites, such as the carboxylic glucuronated metabolite, that may provide a longer detection window than the current ones. Gentili S, Mortali C, Mastrobattista L, Berretta P, Zaami S. 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The development of hyphenated analytical techniques (17, 18) such as ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) is therefore crucial if we want to be able to identify GHB and its precursors in conventional and unconventional biological matrices, bearing in mind the current proposed cut-offs to distinguish between endogenous and exogenous GHB (22). [...]we urge the scientific community investigating GHB to focus on new alternative metabolites, such as the carboxylic glucuronated metabolite, that may provide a longer detection window than the current ones. Gentili S, Mortali C, Mastrobattista L, Berretta P, Zaami S. 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Matanović, Suzana Mimica ; Zibar, Lada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-1b4107847541a9f4c396b66482de06e6e01bee08cb8e89117dd18b88def78b393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>4-Butyrolactone - toxicity</topic><topic>Acids</topic><topic>Addictions</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Assaults</topic><topic>Biomarkers</topic><topic>Butanediol</topic><topic>Butylene Glycols - toxicity</topic><topic>Butyrolactone</topic><topic>Chromatography</topic><topic>Cocaine</topic><topic>Coma</topic><topic>Drug abuse</topic><topic>Drug dosages</topic><topic>Drug testing</topic><topic>Female</topic><topic>Gas chromatography</topic><topic>Hair</topic><topic>Headspace</topic><topic>Health risks</topic><topic>High performance liquid chromatography</topic><topic>Humans</topic><topic>Hydroxybutyrates - toxicity</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Rape</topic><topic>Scientific imaging</topic><topic>Sex crimes</topic><topic>Solid phase methods</topic><topic>Solid phases</topic><topic>Solvents - toxicity</topic><topic>Spectroscopy</topic><topic>Substance-Related Disorders - diagnosis</topic><topic>Substance-Related Disorders - etiology</topic><topic>Sweat</topic><topic>Toxicology</topic><topic>Urine</topic><topic>γ-Hydroxybutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beck, Renata</creatorcontrib><creatorcontrib>Matanović, Suzana Mimica</creatorcontrib><creatorcontrib>Zibar, Lada</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Arhiv za higijenu rada i toksikologiju</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beck, Renata</au><au>Matanović, Suzana Mimica</au><au>Zibar, Lada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol addiction: a serious health threat</atitle><jtitle>Arhiv za higijenu rada i toksikologiju</jtitle><addtitle>Arh Hig Rada Toksikol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>70</volume><issue>2</issue><spage>149</spage><epage>150</epage><pages>149-150</pages><issn>0004-1254</issn><eissn>1848-6312</eissn><eissn>0004-1254</eissn><abstract>[...]its reputation of a rape drug (4, 5). The development of hyphenated analytical techniques (17, 18) such as ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) is therefore crucial if we want to be able to identify GHB and its precursors in conventional and unconventional biological matrices, bearing in mind the current proposed cut-offs to distinguish between endogenous and exogenous GHB (22). [...]we urge the scientific community investigating GHB to focus on new alternative metabolites, such as the carboxylic glucuronated metabolite, that may provide a longer detection window than the current ones. Gentili S, Mortali C, Mastrobattista L, Berretta P, Zaami S. Determination of different recreational drugs in sweat by headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME GC/MS): Application to drugged drivers.</abstract><cop>Croatia</cop><pub>Sciendo</pub><pmid>31246568</pmid><doi>10.2478/aiht-2019-70-3295</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-1254 |
| ispartof | Arhiv za higijenu rada i toksikologiju, 2019-06, Vol.70 (2), p.149-150 |
| issn | 0004-1254 1848-6312 0004-1254 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Walter De Gruyter: Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 4-Butyrolactone - toxicity Acids Addictions Adult Aged Aged, 80 and over Assaults Biomarkers Butanediol Butylene Glycols - toxicity Butyrolactone Chromatography Cocaine Coma Drug abuse Drug dosages Drug testing Female Gas chromatography Hair Headspace Health risks High performance liquid chromatography Humans Hydroxybutyrates - toxicity Liquid chromatography Male Mass spectrometry Mass spectroscopy Metabolites Middle Aged Rape Scientific imaging Sex crimes Solid phase methods Solid phases Solvents - toxicity Spectroscopy Substance-Related Disorders - diagnosis Substance-Related Disorders - etiology Sweat Toxicology Urine γ-Hydroxybutyric acid |
| title | Gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol addiction: a serious health threat |
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