Memantine ameliorates learning and memory disturbance and the behavioral and psychological symptoms of dementia in thiamine-deficient mice

Several studies have reported on the beneficial effects of memantine on behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease. However, the effects of memantine on BPSD-like behaviors in animals have not been well addressed. Here, the effects of memantine...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2019-08, Vol.183, p.6-13
Hauptverfasser:	Makino, Mitsuhiro, Takahashi-Ito, Kaori, Murasawa, Hiroyasu, Pawlak, Akiko, Kashimoto, Yoshinori, Kitano, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anxiety - drug therapy Behavior, Animal - drug effects Behavioral and psychological symptoms of dementia (BPSD) Biogenic Monoamines - metabolism Body Weight - drug effects Dementia - chemically induced Dementia - drug therapy Dementia - psychology Depression - drug therapy Disease Models, Animal Glutamic Acid - metabolism Hippocampus - drug effects Hippocampus - metabolism Locomotion - drug effects Male Maze Learning - drug effects Memantine Memantine - administration & dosage Memantine - pharmacology Memory Memory - drug effects Mice Thiamine Thiamine Deficiency - psychology
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