Ligation of Soluble but Unreactive Peptide Segments in the Chemical Synthesis of Haemophilus Influenzae DNA Ligase

During the total chemical synthesis of the water‐soluble globular Haemophilus Influenzae DNA ligase (Hin‐Lig), we observed the surprising phenomenon of a soluble peptide segment that failed to undergo native chemical ligation. Based on dynamic light scattering and transmission electron microscopy ex...

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Veröffentlicht in:	Angewandte Chemie International Edition 2019-08, Vol.58 (35), p.12231-12237
Hauptverfasser:	Zhang, Baochang, Deng, Qiang, Zuo, Chong, Yan, Bingjia, Zuo, Chao, Cao, Xiu‐Xiu, Zhu, Ting F., Zheng, Ji‐Shen, Liu, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	backbone modification Chemical synthesis Colloids Deoxyribonucleic acid DNA DNA biosynthesis DNA ligase Guanidine hydrochloride Haemophilus Light scattering Membrane proteins mirror-image biology native chemical ligation Organic chemistry Peptides Photon correlation spectroscopy proteins Transmission electron microscopy
Online-Zugang:	Volltext
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