Exposure-response analysis of drug-induced QT interval prolongation in telemetered monkeys for translational prediction to human

The preclinical in vivo assay for QT prolongation is critical for predicting torsadogenic risk, but still difficult to extrapolate to humans. This study ran preclinical tests in cynomolgus monkeys on seven QT reference drugs containing the drugs used in the IQ-CSRC clinical trial and applied exposur...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2019-09, Vol.99, p.106606-106606, Article 106606
Hauptverfasser:	Komatsu, Ryuichi, Mizuno, Hiroshi, Ishizaka, Tomomichi, Ito, Akihito, Jikuzono, Tatsuya, Kakoi, Tadashi, Bando, Masahiro, Koga, Tadashi, Handa, Jun, Takahashi, Yukio, Kanno, Akihiro, Ozaki, Harushige, Chiba, Katsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cynomolgus monkey Exposure-response analysis J-ICET Methods Preclinical-clinical concordance Probabilistic QT analysis QT interval prolongation QT rate-correction Safety pharmacology Telemetry
Online-Zugang:	Volltext
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