Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial
Background Gut microbiota likely impact obesity and metabolic diseases. We evaluated the changes in gut microbiota after surgical versus medical weight loss in adults with diabetes and obesity. Methods We performed 16S rRNA amplicon sequencing to identify the gut microbial composition at baseline an...
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| Veröffentlicht in: | Obesity surgery 2019-10, Vol.29 (10), p.3239-3245 |
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| creator | Lee, Clare J. Florea, Liliana Sears, Cynthia L. Maruthur, Nisa Potter, James J. Schweitzer, Michael Magnuson, Thomas Clark, Jeanne M. |
| description | Background
Gut microbiota likely impact obesity and metabolic diseases. We evaluated the changes in gut microbiota after surgical versus medical weight loss in adults with diabetes and obesity.
Methods
We performed 16S rRNA amplicon sequencing to identify the gut microbial composition at baseline and at 10% weight loss in adults with diabetes who were randomized to medical weight loss (MWL,
n
= 4), adjustable gastric banding (AGB,
n
= 4), or Roux-en-Y gastric bypass (RYGB,
n
= 4).
Results
All participants were female, 75% reported black race with mean age of 51 years. At similar weight loss amount and glycemic improvement, the RYGB group had the most number of bacterial species (10 increased, 1 decreased) that significantly changed (
p
|
| doi_str_mv | 10.1007/s11695-019-03976-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2250634215</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2250634215</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-c5f0adc862968bbcb7e1fdb00b2cf6b878df9cb54094ae62ad5de7343ac0ea343</originalsourceid><addsrcrecordid>eNp9kT1vFDEQhi1ERC6BP0CBLNHQLIzttXddwgkSpIsShQCl5Y_ZO0f7EezdIvx6fLkAEgXVFPPMO6N5CHnJ4C0DaN5lxpSWFTBdgdCNquonZMUaaCuoefuUrEArqFrNxTE5yfkWgDPF-TNyLBiXSki1Irv1zo5bzDSO9GyZ6UX0aXJxGpDabsZEP9gU7Zyip1-WtMV0T79hykumFxiitz39jnG7m-lmyg8hll7FfprptR3DNMSfGOhNSeifk6PO9hlfPNZT8vXTx5v1ebW5PPu8fr-pvGjkXHnZgQ2-VVyr1jnvGmRdcACO-065tmlDp72TNejaouI2yICNqIX1gLbUU_LmkHuXph8L5tkMMXvsezvitGTDuQQlas5kQV__g95OSxrLdYWqtWCMt3uKH6jymJwTduYuxcGme8PA7D2YgwdTPJgHD2Z_xavH6MUNGP6M_H58AcQByKVVBKS_u_8T-wu53JNr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2249311285</pqid></control><display><type>article</type><title>Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Lee, Clare J. ; Florea, Liliana ; Sears, Cynthia L. ; Maruthur, Nisa ; Potter, James J. ; Schweitzer, Michael ; Magnuson, Thomas ; Clark, Jeanne M.</creator><creatorcontrib>Lee, Clare J. ; Florea, Liliana ; Sears, Cynthia L. ; Maruthur, Nisa ; Potter, James J. ; Schweitzer, Michael ; Magnuson, Thomas ; Clark, Jeanne M.</creatorcontrib><description>Background
Gut microbiota likely impact obesity and metabolic diseases. We evaluated the changes in gut microbiota after surgical versus medical weight loss in adults with diabetes and obesity.
Methods
We performed 16S rRNA amplicon sequencing to identify the gut microbial composition at baseline and at 10% weight loss in adults with diabetes who were randomized to medical weight loss (MWL,
n
= 4), adjustable gastric banding (AGB,
n
= 4), or Roux-en-Y gastric bypass (RYGB,
n
= 4).
Results
All participants were female, 75% reported black race with mean age of 51 years. At similar weight loss amount and glycemic improvement, the RYGB group had the most number of bacterial species (10 increased, 1 decreased) that significantly changed (
p
< 0.05) in relative abundance. Alpha-diversity at follow-up was significantly lower in AGB group compared to MWL and RYGB (observed species for AGB vs. MWL,
p
= 0.0093; AGB vs. RYGB,
p
= 0.0093). The relative abundance of
Faecalibacterium prausnitzii
increased in 3 participants after RYGB, 1 after AGB, and 1 after MWL.
Conclusions
At similar weight loss and glycemic improvement, the greatest alteration in gut microbiota occurred after RYGB with an increase in the potentially beneficial bacterium,
F. prausnitzii
. Gut microbial diversity tended to decrease after AGB and increase after RYGB and MWL. Future studies are needed to determine the impact and durability of gut microbial changes over time and their role in long-term metabolic improvement after bariatric surgery in adults with type 2 diabetes.
Clinical Trial Registration
NCTDK089557—
ClinicalTrials.gov</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-019-03976-4</identifier><identifier>PMID: 31256356</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Bacteria - classification ; Bacteria - genetics ; Bacteria - isolation & purification ; Bacterial Typing Techniques ; Bariatric Surgery - methods ; Biodiversity ; Blood Glucose - metabolism ; Diabetes ; Diabetes Mellitus, Type 2 - microbiology ; Diabetes Mellitus, Type 2 - surgery ; Digestive system ; Feces - microbiology ; Female ; Gastric Bypass ; Gastrointestinal Microbiome - physiology ; Gastrointestinal surgery ; Gastroplasty ; Humans ; Medicine ; Medicine & Public Health ; Metabolism ; Microbiota ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - microbiology ; Obesity - surgery ; Obesity, Morbid - blood ; Obesity, Morbid - microbiology ; Obesity, Morbid - surgery ; Original Contributions ; Pilot Projects ; Postoperative Period ; RNA, Ribosomal, 16S - genetics ; Surgery ; Weight control ; Weight Loss - physiology</subject><ispartof>Obesity surgery, 2019-10, Vol.29 (10), p.3239-3245</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Obesity Surgery is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c5f0adc862968bbcb7e1fdb00b2cf6b878df9cb54094ae62ad5de7343ac0ea343</citedby><cites>FETCH-LOGICAL-c375t-c5f0adc862968bbcb7e1fdb00b2cf6b878df9cb54094ae62ad5de7343ac0ea343</cites><orcidid>0000-0002-0824-0207</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-019-03976-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-019-03976-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31256356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Clare J.</creatorcontrib><creatorcontrib>Florea, Liliana</creatorcontrib><creatorcontrib>Sears, Cynthia L.</creatorcontrib><creatorcontrib>Maruthur, Nisa</creatorcontrib><creatorcontrib>Potter, James J.</creatorcontrib><creatorcontrib>Schweitzer, Michael</creatorcontrib><creatorcontrib>Magnuson, Thomas</creatorcontrib><creatorcontrib>Clark, Jeanne M.</creatorcontrib><title>Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Gut microbiota likely impact obesity and metabolic diseases. We evaluated the changes in gut microbiota after surgical versus medical weight loss in adults with diabetes and obesity.
Methods
We performed 16S rRNA amplicon sequencing to identify the gut microbial composition at baseline and at 10% weight loss in adults with diabetes who were randomized to medical weight loss (MWL,
n
= 4), adjustable gastric banding (AGB,
n
= 4), or Roux-en-Y gastric bypass (RYGB,
n
= 4).
Results
All participants were female, 75% reported black race with mean age of 51 years. At similar weight loss amount and glycemic improvement, the RYGB group had the most number of bacterial species (10 increased, 1 decreased) that significantly changed (
p
< 0.05) in relative abundance. Alpha-diversity at follow-up was significantly lower in AGB group compared to MWL and RYGB (observed species for AGB vs. MWL,
p
= 0.0093; AGB vs. RYGB,
p
= 0.0093). The relative abundance of
Faecalibacterium prausnitzii
increased in 3 participants after RYGB, 1 after AGB, and 1 after MWL.
Conclusions
At similar weight loss and glycemic improvement, the greatest alteration in gut microbiota occurred after RYGB with an increase in the potentially beneficial bacterium,
F. prausnitzii
. Gut microbial diversity tended to decrease after AGB and increase after RYGB and MWL. Future studies are needed to determine the impact and durability of gut microbial changes over time and their role in long-term metabolic improvement after bariatric surgery in adults with type 2 diabetes.
Clinical Trial Registration
NCTDK089557—
ClinicalTrials.gov</description><subject>Adult</subject><subject>Bacteria - classification</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Bacterial Typing Techniques</subject><subject>Bariatric Surgery - methods</subject><subject>Biodiversity</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - microbiology</subject><subject>Diabetes Mellitus, Type 2 - surgery</subject><subject>Digestive system</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gastrointestinal surgery</subject><subject>Gastroplasty</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - microbiology</subject><subject>Obesity - surgery</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - microbiology</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Pilot Projects</subject><subject>Postoperative Period</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Surgery</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kT1vFDEQhi1ERC6BP0CBLNHQLIzttXddwgkSpIsShQCl5Y_ZO0f7EezdIvx6fLkAEgXVFPPMO6N5CHnJ4C0DaN5lxpSWFTBdgdCNquonZMUaaCuoefuUrEArqFrNxTE5yfkWgDPF-TNyLBiXSki1Irv1zo5bzDSO9GyZ6UX0aXJxGpDabsZEP9gU7Zyip1-WtMV0T79hykumFxiitz39jnG7m-lmyg8hll7FfprptR3DNMSfGOhNSeifk6PO9hlfPNZT8vXTx5v1ebW5PPu8fr-pvGjkXHnZgQ2-VVyr1jnvGmRdcACO-065tmlDp72TNejaouI2yICNqIX1gLbUU_LmkHuXph8L5tkMMXvsezvitGTDuQQlas5kQV__g95OSxrLdYWqtWCMt3uKH6jymJwTduYuxcGme8PA7D2YgwdTPJgHD2Z_xavH6MUNGP6M_H58AcQByKVVBKS_u_8T-wu53JNr</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Lee, Clare J.</creator><creator>Florea, Liliana</creator><creator>Sears, Cynthia L.</creator><creator>Maruthur, Nisa</creator><creator>Potter, James J.</creator><creator>Schweitzer, Michael</creator><creator>Magnuson, Thomas</creator><creator>Clark, Jeanne M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0824-0207</orcidid></search><sort><creationdate>20191001</creationdate><title>Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial</title><author>Lee, Clare J. ; Florea, Liliana ; Sears, Cynthia L. ; Maruthur, Nisa ; Potter, James J. ; Schweitzer, Michael ; Magnuson, Thomas ; Clark, Jeanne M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-c5f0adc862968bbcb7e1fdb00b2cf6b878df9cb54094ae62ad5de7343ac0ea343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Bacteria - classification</topic><topic>Bacteria - genetics</topic><topic>Bacteria - isolation & purification</topic><topic>Bacterial Typing Techniques</topic><topic>Bariatric Surgery - methods</topic><topic>Biodiversity</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - microbiology</topic><topic>Diabetes Mellitus, Type 2 - surgery</topic><topic>Digestive system</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Gastrointestinal surgery</topic><topic>Gastroplasty</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - microbiology</topic><topic>Obesity - surgery</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - microbiology</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Pilot Projects</topic><topic>Postoperative Period</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Surgery</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Clare J.</creatorcontrib><creatorcontrib>Florea, Liliana</creatorcontrib><creatorcontrib>Sears, Cynthia L.</creatorcontrib><creatorcontrib>Maruthur, Nisa</creatorcontrib><creatorcontrib>Potter, James J.</creatorcontrib><creatorcontrib>Schweitzer, Michael</creatorcontrib><creatorcontrib>Magnuson, Thomas</creatorcontrib><creatorcontrib>Clark, Jeanne M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Clare J.</au><au>Florea, Liliana</au><au>Sears, Cynthia L.</au><au>Maruthur, Nisa</au><au>Potter, James J.</au><au>Schweitzer, Michael</au><au>Magnuson, Thomas</au><au>Clark, Jeanne M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>29</volume><issue>10</issue><spage>3239</spage><epage>3245</epage><pages>3239-3245</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Gut microbiota likely impact obesity and metabolic diseases. We evaluated the changes in gut microbiota after surgical versus medical weight loss in adults with diabetes and obesity.
Methods
We performed 16S rRNA amplicon sequencing to identify the gut microbial composition at baseline and at 10% weight loss in adults with diabetes who were randomized to medical weight loss (MWL,
n
= 4), adjustable gastric banding (AGB,
n
= 4), or Roux-en-Y gastric bypass (RYGB,
n
= 4).
Results
All participants were female, 75% reported black race with mean age of 51 years. At similar weight loss amount and glycemic improvement, the RYGB group had the most number of bacterial species (10 increased, 1 decreased) that significantly changed (
p
< 0.05) in relative abundance. Alpha-diversity at follow-up was significantly lower in AGB group compared to MWL and RYGB (observed species for AGB vs. MWL,
p
= 0.0093; AGB vs. RYGB,
p
= 0.0093). The relative abundance of
Faecalibacterium prausnitzii
increased in 3 participants after RYGB, 1 after AGB, and 1 after MWL.
Conclusions
At similar weight loss and glycemic improvement, the greatest alteration in gut microbiota occurred after RYGB with an increase in the potentially beneficial bacterium,
F. prausnitzii
. Gut microbial diversity tended to decrease after AGB and increase after RYGB and MWL. Future studies are needed to determine the impact and durability of gut microbial changes over time and their role in long-term metabolic improvement after bariatric surgery in adults with type 2 diabetes.
Clinical Trial Registration
NCTDK089557—
ClinicalTrials.gov</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31256356</pmid><doi>10.1007/s11695-019-03976-4</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0824-0207</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Obesity surgery, 2019-10, Vol.29 (10), p.3239-3245 |
| issn | 0960-8923 1708-0428 |
| language | eng |
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| subjects | Adult Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Bacterial Typing Techniques Bariatric Surgery - methods Biodiversity Blood Glucose - metabolism Diabetes Diabetes Mellitus, Type 2 - microbiology Diabetes Mellitus, Type 2 - surgery Digestive system Feces - microbiology Female Gastric Bypass Gastrointestinal Microbiome - physiology Gastrointestinal surgery Gastroplasty Humans Medicine Medicine & Public Health Metabolism Microbiota Middle Aged Obesity Obesity - blood Obesity - microbiology Obesity - surgery Obesity, Morbid - blood Obesity, Morbid - microbiology Obesity, Morbid - surgery Original Contributions Pilot Projects Postoperative Period RNA, Ribosomal, 16S - genetics Surgery Weight control Weight Loss - physiology |
| title | Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial |
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