Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells
[Display omitted] Mahanine (MH), a carbazole alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits the growth of altered subtypes of breast cancer cells in vitro and significantly reduced the mammary tumor burden in N-Methyl-N-nitrosourea (MNU) induced rat. The experimental...
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| Veröffentlicht in: | Pharmacological research 2019-08, Vol.146, p.104330-104330, Article 104330 |
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| creator | Das, Momita Kandimalla, Raghuram Gogoi, Bhaskarjyoti Dutta, Krishna Nayani Choudhury, Paramita Devi, Rajlakshmi Dutta, Partha Pratim Talukdar, Narayan Chandra Samanta, Suman Kumar |
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Mahanine (MH), a carbazole alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits the growth of altered subtypes of breast cancer cells in vitro and significantly reduced the mammary tumor burden in N-Methyl-N-nitrosourea (MNU) induced rat. The experimental results showed that 20–25 μM of MH for 24 h of treatment was very potent to reduce the cell proliferation through apoptosis with arresting the cells in G0/G1 in both ER+/p53WT MCF-7 and triple negative/p53Mut MDA-MB-231 cells. On the other hand, 10–15 μM of MH exposure to those two cell lines, caused inhibition of mammosphere formation and reduction of CD44high/CD24low/epithelial-specific antigen-positive (ESA+) population, which ultimately led to loss of self-renewal ability of breast cancer stem cells. Further, in vivo observation indicated that intraperitoneal injection of MH for four weeks with a dose of 50 mg/kg body weight thrice in a week, significantly (P = 0.03) reduced the mammary tumor weight in MNU induced rat. In conclusion, this study provides the novel insight into the mechanism of MH mediated growth arrest in subtype irrespective breast cancer progression. |
| doi_str_mv | 10.1016/j.phrs.2019.104330 |
| format | Article |
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Mahanine (MH), a carbazole alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits the growth of altered subtypes of breast cancer cells in vitro and significantly reduced the mammary tumor burden in N-Methyl-N-nitrosourea (MNU) induced rat. The experimental results showed that 20–25 μM of MH for 24 h of treatment was very potent to reduce the cell proliferation through apoptosis with arresting the cells in G0/G1 in both ER+/p53WT MCF-7 and triple negative/p53Mut MDA-MB-231 cells. On the other hand, 10–15 μM of MH exposure to those two cell lines, caused inhibition of mammosphere formation and reduction of CD44high/CD24low/epithelial-specific antigen-positive (ESA+) population, which ultimately led to loss of self-renewal ability of breast cancer stem cells. Further, in vivo observation indicated that intraperitoneal injection of MH for four weeks with a dose of 50 mg/kg body weight thrice in a week, significantly (P = 0.03) reduced the mammary tumor weight in MNU induced rat. In conclusion, this study provides the novel insight into the mechanism of MH mediated growth arrest in subtype irrespective breast cancer progression.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2019.104330</identifier><identifier>PMID: 31251988</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Apoptosis - drug effects ; Breast - drug effects ; Breast - metabolism ; Breast - pathology ; Breast cancer stem cells (bCSC) ; Breast Neoplasms - drug therapy ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carbazoles - pharmacology ; Cell Cycle Checkpoints - drug effects ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Diet ; Disease Progression ; Female ; G1 Phase - drug effects ; Humans ; In vivo ; Mahanine ; Mammary Neoplasms, Animal - drug therapy ; Mammary Neoplasms, Animal - metabolism ; Mammary Neoplasms, Animal - pathology ; MCF-7 Cells ; Murraya koenigii ; N-methyl-N-nitrosourea (MNU) ; Neoplastic Stem Cells - drug effects ; Neoplastic Stem Cells - metabolism ; Neoplastic Stem Cells - pathology ; Phytochemicals - pharmacology ; Rats ; Resting Phase, Cell Cycle - drug effects ; Tumor Burden - drug effects</subject><ispartof>Pharmacological research, 2019-08, Vol.146, p.104330-104330, Article 104330</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-de6e5c9bca4a96fda23510f85e3aeecafa9a74b962a2d452abb91164e71ffc803</citedby><cites>FETCH-LOGICAL-c356t-de6e5c9bca4a96fda23510f85e3aeecafa9a74b962a2d452abb91164e71ffc803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phrs.2019.104330$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31251988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, Momita</creatorcontrib><creatorcontrib>Kandimalla, Raghuram</creatorcontrib><creatorcontrib>Gogoi, Bhaskarjyoti</creatorcontrib><creatorcontrib>Dutta, Krishna Nayani</creatorcontrib><creatorcontrib>Choudhury, Paramita</creatorcontrib><creatorcontrib>Devi, Rajlakshmi</creatorcontrib><creatorcontrib>Dutta, Partha Pratim</creatorcontrib><creatorcontrib>Talukdar, Narayan Chandra</creatorcontrib><creatorcontrib>Samanta, Suman Kumar</creatorcontrib><title>Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>[Display omitted]
Mahanine (MH), a carbazole alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits the growth of altered subtypes of breast cancer cells in vitro and significantly reduced the mammary tumor burden in N-Methyl-N-nitrosourea (MNU) induced rat. The experimental results showed that 20–25 μM of MH for 24 h of treatment was very potent to reduce the cell proliferation through apoptosis with arresting the cells in G0/G1 in both ER+/p53WT MCF-7 and triple negative/p53Mut MDA-MB-231 cells. On the other hand, 10–15 μM of MH exposure to those two cell lines, caused inhibition of mammosphere formation and reduction of CD44high/CD24low/epithelial-specific antigen-positive (ESA+) population, which ultimately led to loss of self-renewal ability of breast cancer stem cells. Further, in vivo observation indicated that intraperitoneal injection of MH for four weeks with a dose of 50 mg/kg body weight thrice in a week, significantly (P = 0.03) reduced the mammary tumor weight in MNU induced rat. In conclusion, this study provides the novel insight into the mechanism of MH mediated growth arrest in subtype irrespective breast cancer progression.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Breast - drug effects</subject><subject>Breast - metabolism</subject><subject>Breast - pathology</subject><subject>Breast cancer stem cells (bCSC)</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carbazoles - pharmacology</subject><subject>Cell Cycle Checkpoints - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Diet</subject><subject>Disease Progression</subject><subject>Female</subject><subject>G1 Phase - drug effects</subject><subject>Humans</subject><subject>In vivo</subject><subject>Mahanine</subject><subject>Mammary Neoplasms, Animal - drug therapy</subject><subject>Mammary Neoplasms, Animal - metabolism</subject><subject>Mammary Neoplasms, Animal - pathology</subject><subject>MCF-7 Cells</subject><subject>Murraya koenigii</subject><subject>N-methyl-N-nitrosourea (MNU)</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Phytochemicals - pharmacology</subject><subject>Rats</subject><subject>Resting Phase, Cell Cycle - drug effects</subject><subject>Tumor Burden - drug effects</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO1DAQRS0EYoaBH2CBvGQxaew83InEZjTiJQ1iA2urYlc6biV2cDmD-uv4NRx6YMGClUvWPbcel7GXUuykkOrNcbeMkXalkF3-qKtKPGKXUnSqkLJVj7e6rgqlZHvBnhEdhRBdLcVTdlHJspFd216yn59hBO88XvMbbh0miCe-jKcUzIizMzBd84hLRCIkPsM8b4K0ziHyfo0WPXeeR0gcvM3l6HqXiNPap9OCGT1AtFOmeR8RKHED3mDkSwyHzdQFz9MYw3oYM7T8buT8gRNOQxHR4w-YeBj-oSnhzA1OEz1nTwaYCF88vFfs2_t3X28_FndfPny6vbkrTNWoVFhU2JiuN1BDpwYLZdVIMbQNVoBoYIAO9nXfqRJKWzcl9H0npapxL4fBtKK6Yq_Pvnnw7ytS0rOjbQLwGFbSZdkIVQnV7LO0PEtNDEQRB71Et51NS6G34PRRb8HpLTh9Di5Drx78135G-xf5k1QWvD0LMG957zBqMg7zNayLaJK2wf3P_xcgp7CN</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Das, Momita</creator><creator>Kandimalla, Raghuram</creator><creator>Gogoi, Bhaskarjyoti</creator><creator>Dutta, Krishna Nayani</creator><creator>Choudhury, Paramita</creator><creator>Devi, Rajlakshmi</creator><creator>Dutta, Partha Pratim</creator><creator>Talukdar, Narayan Chandra</creator><creator>Samanta, Suman Kumar</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells</title><author>Das, Momita ; Kandimalla, Raghuram ; Gogoi, Bhaskarjyoti ; Dutta, Krishna Nayani ; Choudhury, Paramita ; Devi, Rajlakshmi ; Dutta, Partha Pratim ; Talukdar, Narayan Chandra ; Samanta, Suman Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-de6e5c9bca4a96fda23510f85e3aeecafa9a74b962a2d452abb91164e71ffc803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Breast - drug effects</topic><topic>Breast - metabolism</topic><topic>Breast - pathology</topic><topic>Breast cancer stem cells (bCSC)</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carbazoles - pharmacology</topic><topic>Cell Cycle Checkpoints - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Diet</topic><topic>Disease Progression</topic><topic>Female</topic><topic>G1 Phase - drug effects</topic><topic>Humans</topic><topic>In vivo</topic><topic>Mahanine</topic><topic>Mammary Neoplasms, Animal - drug therapy</topic><topic>Mammary Neoplasms, Animal - metabolism</topic><topic>Mammary Neoplasms, Animal - pathology</topic><topic>MCF-7 Cells</topic><topic>Murraya koenigii</topic><topic>N-methyl-N-nitrosourea (MNU)</topic><topic>Neoplastic Stem Cells - drug effects</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Phytochemicals - pharmacology</topic><topic>Rats</topic><topic>Resting Phase, Cell Cycle - drug effects</topic><topic>Tumor Burden - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, Momita</creatorcontrib><creatorcontrib>Kandimalla, Raghuram</creatorcontrib><creatorcontrib>Gogoi, Bhaskarjyoti</creatorcontrib><creatorcontrib>Dutta, Krishna Nayani</creatorcontrib><creatorcontrib>Choudhury, Paramita</creatorcontrib><creatorcontrib>Devi, Rajlakshmi</creatorcontrib><creatorcontrib>Dutta, Partha Pratim</creatorcontrib><creatorcontrib>Talukdar, Narayan Chandra</creatorcontrib><creatorcontrib>Samanta, Suman Kumar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, Momita</au><au>Kandimalla, Raghuram</au><au>Gogoi, Bhaskarjyoti</au><au>Dutta, Krishna Nayani</au><au>Choudhury, Paramita</au><au>Devi, Rajlakshmi</au><au>Dutta, Partha Pratim</au><au>Talukdar, Narayan Chandra</au><au>Samanta, Suman Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2019-08</date><risdate>2019</risdate><volume>146</volume><spage>104330</spage><epage>104330</epage><pages>104330-104330</pages><artnum>104330</artnum><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>[Display omitted]
Mahanine (MH), a carbazole alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits the growth of altered subtypes of breast cancer cells in vitro and significantly reduced the mammary tumor burden in N-Methyl-N-nitrosourea (MNU) induced rat. The experimental results showed that 20–25 μM of MH for 24 h of treatment was very potent to reduce the cell proliferation through apoptosis with arresting the cells in G0/G1 in both ER+/p53WT MCF-7 and triple negative/p53Mut MDA-MB-231 cells. On the other hand, 10–15 μM of MH exposure to those two cell lines, caused inhibition of mammosphere formation and reduction of CD44high/CD24low/epithelial-specific antigen-positive (ESA+) population, which ultimately led to loss of self-renewal ability of breast cancer stem cells. Further, in vivo observation indicated that intraperitoneal injection of MH for four weeks with a dose of 50 mg/kg body weight thrice in a week, significantly (P = 0.03) reduced the mammary tumor weight in MNU induced rat. In conclusion, this study provides the novel insight into the mechanism of MH mediated growth arrest in subtype irrespective breast cancer progression.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>31251988</pmid><doi>10.1016/j.phrs.2019.104330</doi><tpages>1</tpages></addata></record> |
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| subjects | Animals Apoptosis - drug effects Breast - drug effects Breast - metabolism Breast - pathology Breast cancer stem cells (bCSC) Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Carbazoles - pharmacology Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Proliferation - drug effects Diet Disease Progression Female G1 Phase - drug effects Humans In vivo Mahanine Mammary Neoplasms, Animal - drug therapy Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology MCF-7 Cells Murraya koenigii N-methyl-N-nitrosourea (MNU) Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phytochemicals - pharmacology Rats Resting Phase, Cell Cycle - drug effects Tumor Burden - drug effects |
| title | Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells |
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