Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X‑ray Crystallography

Epimeric series of aryl-substituted glucopyranosylidene-spiro-imidazolinones, an unprecedented new ring system, were synthesized from the corresponding Schiff bases of O-perbenzoylated (gluculopyranosylamine)­onamides by intramolecular ring closure of the aldimine moieties with the carboxamide group...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-07, Vol.62 (13), p.6116-6136
Hauptverfasser:	Szabó, Katalin E, Kyriakis, Efthimios, Psarra, Anna-Maria G, Karra, Aikaterini G, Sipos, Ádám, Docsa, Tibor, Stravodimos, George A, Katsidou, Elisabeth, Skamnaki, Vassiliki T, Liggri, Panagiota G. V, Zographos, Spyros E, Mándi, Attila, Király, Sándor Balázs, Kurtán, Tibor, Leonidas, Demetres D, Somsák, László
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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