Linking myofibroblast generation and microvascular alteration: The role of CD248 from pathogenesis to therapeutic target (Review)

Fibrosis is characterized by excessive extracellular matrix (ECM) deposition, and is the pathological outcome of tissue injury in a number of disorders. Accumulation of the ECM may disrupt the structure and function of native tissues and organs, including the lungs, heart, liver and skin, resulting...

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Veröffentlicht in:	Molecular medicine reports 2019-08, Vol.20 (2), p.1488-1498
Hauptverfasser:	Di Benedetto, Paola, Ruscitti, Piero, Liakouli, Vasiliki, Del Galdo, Francesco, Giacomelli, Roberto, Cipriani, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - therapeutic use Animals Antibodies, Monoclonal - therapeutic use Antigens, CD - genetics Antigens, CD - metabolism Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Antineoplastic Agents, Immunological - therapeutic use Cancer Clinical Trials as Topic Collagen - genetics Collagen - metabolism Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - pathology Fibroblasts Fibrosis Fibrosis - prevention & control Gene Expression Regulation Growth factors Health aspects Humans Liver Lungs Microvasculature Morbidity Mortality Myofibroblasts - drug effects Myofibroblasts - metabolism Myofibroblasts - pathology Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Pathogenesis Proteins Signal Transduction Skin Structure-function relationships Therapeutic applications Tumors
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