miR‑425‑5p promotes cell proliferation, migration and invasion by directly targeting FOXD3 in hepatocellular carcinoma cells

MicroRNAs (miRs) are important regulators of the tumorigenesis and metastasis of various cancers. In the present study, the roles and underlying mechanisms of miR‑425‑5p in the development of hepatocellular carcinoma (HCC) were investigated. RT‑qPCR analysis revealed that miR‑425‑5p was upregulated...

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Veröffentlicht in:	Molecular medicine reports 2019-08, Vol.20 (2), p.1883-1892
Hauptverfasser:	Wu, Hewen, Shang, Jia, Zhan, Weili, Liu, Junping, Ning, Huibin, Chen, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Apoptosis Biotechnology industries Cancer Cancer metastasis Cancer research Carcinogenesis - genetics Carcinoma Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell culture Cell growth Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Epithelial-Mesenchymal Transition - genetics Female Forkhead protein Forkhead Transcription Factors - genetics Gene expression Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Humans Kinases Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Male Medical prognosis Melanoma Mesenchyme Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miRNA Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Novels Patients Proteins Roles Scientific equipment industry Stem cells Studies Tumorigenesis Tumors Vascular endothelial growth factor
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