Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Ageing Brains with Special Reference to Menopause and Neurocognitive Disorders
The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neu...
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| Veröffentlicht in: | Neurochemical research 2019-08, Vol.44 (8), p.1781-1795 |
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| creator | Kandasamy, Mahesh Radhakrishnan, Risna Kanjirassery Poornimai Abirami, G. P. Roshan, Syed Aasish Yesudhas, Ajisha Balamuthu, Kadalmani Prahalathan, Chidambaram Shanmugaapriya, Sellathamby Moorthy, Anbalagan Essa, Musthafa Mohamed Anusuyadevi, Muthuswamy |
| description | The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocampal plasticity has been proposed to be regulated via neuroblasts, a major cellular determinant of functional neurogenesis in the adult brain. Defects in differentiation, integration and survival of neuroblasts in the hippocampus appear to be an underlying cause of neurocognitive disorders. Gonadotropin receptors and steroidogenic enzymes have been found to be expressed in neuroblasts in the hippocampus of the brain. However, the reciprocal relationship between hippocampal-specific neuroestradiol synthesis along neuroblastosis and response of pituitary based feedback regulation towards regulation of estradiol level in the hippocampus have not completely been ascertained. Therefore, this conceptual article revisits (1) the cellular basis of neuroestradiol synthesis (2) a potential relationship between neuroestradiol synthesis and neuroblastosis in the hippocampus (3) the possible involvement of aberrant neuroestradiol production with mitochondrial dysfunctions and dyslipidemia in menopause and adult-onset neurodegenerative disorders and (4) provides a hypothesis for the possible existence of the hypothalamic-pituitary-hippocampal (HPH) axis in the adult brain. Eventually, understanding the regulation of hippocampal neurogenesis by abnormal levels of neuroestradiol concentration in association with the feedback regulation of HPH axis might provide additional cues to establish a neuroregenerative therapeutic management for mood swings, depression and cognitive decline in menopause and neurocognitive disorders. |
| doi_str_mv | 10.1007/s11064-019-02833-1 |
| format | Article |
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P. ; Roshan, Syed Aasish ; Yesudhas, Ajisha ; Balamuthu, Kadalmani ; Prahalathan, Chidambaram ; Shanmugaapriya, Sellathamby ; Moorthy, Anbalagan ; Essa, Musthafa Mohamed ; Anusuyadevi, Muthuswamy</creator><creatorcontrib>Kandasamy, Mahesh ; Radhakrishnan, Risna Kanjirassery ; Poornimai Abirami, G. P. ; Roshan, Syed Aasish ; Yesudhas, Ajisha ; Balamuthu, Kadalmani ; Prahalathan, Chidambaram ; Shanmugaapriya, Sellathamby ; Moorthy, Anbalagan ; Essa, Musthafa Mohamed ; Anusuyadevi, Muthuswamy</creatorcontrib><description>The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocampal plasticity has been proposed to be regulated via neuroblasts, a major cellular determinant of functional neurogenesis in the adult brain. Defects in differentiation, integration and survival of neuroblasts in the hippocampus appear to be an underlying cause of neurocognitive disorders. Gonadotropin receptors and steroidogenic enzymes have been found to be expressed in neuroblasts in the hippocampus of the brain. However, the reciprocal relationship between hippocampal-specific neuroestradiol synthesis along neuroblastosis and response of pituitary based feedback regulation towards regulation of estradiol level in the hippocampus have not completely been ascertained. Therefore, this conceptual article revisits (1) the cellular basis of neuroestradiol synthesis (2) a potential relationship between neuroestradiol synthesis and neuroblastosis in the hippocampus (3) the possible involvement of aberrant neuroestradiol production with mitochondrial dysfunctions and dyslipidemia in menopause and adult-onset neurodegenerative disorders and (4) provides a hypothesis for the possible existence of the hypothalamic-pituitary-hippocampal (HPH) axis in the adult brain. Eventually, understanding the regulation of hippocampal neurogenesis by abnormal levels of neuroestradiol concentration in association with the feedback regulation of HPH axis might provide additional cues to establish a neuroregenerative therapeutic management for mood swings, depression and cognitive decline in menopause and neurocognitive disorders.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-019-02833-1</identifier><identifier>PMID: 31254250</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>17β-Estradiol ; Aging ; Aging - physiology ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Cognition ; Cognitive ability ; Disorders ; Dyslipidemia ; Estradiol - biosynthesis ; Estradiol - metabolism ; Feedback ; Female ; Functional plasticity ; Gonadotropins ; Gonads ; Hippocampal plasticity ; Hippocampus ; Hippocampus - physiology ; Hippocampus - physiopathology ; Humans ; Hypothalamus ; Menopause ; Menopause - physiology ; Mental depression ; Mitochondria ; Mitochondrial Diseases - physiopathology ; Mood ; Nervous system ; Neuroblasts ; Neurochemistry ; Neurodegenerative diseases ; Neurodegenerative Diseases - physiopathology ; Neurogenesis ; Neurogenesis - physiology ; Neurology ; Neuronal Plasticity - physiology ; Neuroplasticity ; Neurosciences ; Pituitary ; Pituitary (anterior) ; Pituitary Gland - physiology ; Pituitary Gland - physiopathology ; Receptors ; Review ; Sex hormones ; Synthesis</subject><ispartof>Neurochemical research, 2019-08, Vol.44 (8), p.1781-1795</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Neurochemical Research is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e23ffa48c6ea2635dbb87d0275d0b8c7d2095a66c4512773ebba2038ac590253</citedby><cites>FETCH-LOGICAL-c375t-e23ffa48c6ea2635dbb87d0275d0b8c7d2095a66c4512773ebba2038ac590253</cites><orcidid>0000-0002-6720-9082</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-019-02833-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-019-02833-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31254250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kandasamy, Mahesh</creatorcontrib><creatorcontrib>Radhakrishnan, Risna Kanjirassery</creatorcontrib><creatorcontrib>Poornimai Abirami, G. P.</creatorcontrib><creatorcontrib>Roshan, Syed Aasish</creatorcontrib><creatorcontrib>Yesudhas, Ajisha</creatorcontrib><creatorcontrib>Balamuthu, Kadalmani</creatorcontrib><creatorcontrib>Prahalathan, Chidambaram</creatorcontrib><creatorcontrib>Shanmugaapriya, Sellathamby</creatorcontrib><creatorcontrib>Moorthy, Anbalagan</creatorcontrib><creatorcontrib>Essa, Musthafa Mohamed</creatorcontrib><creatorcontrib>Anusuyadevi, Muthuswamy</creatorcontrib><title>Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Ageing Brains with Special Reference to Menopause and Neurocognitive Disorders</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocampal plasticity has been proposed to be regulated via neuroblasts, a major cellular determinant of functional neurogenesis in the adult brain. Defects in differentiation, integration and survival of neuroblasts in the hippocampus appear to be an underlying cause of neurocognitive disorders. Gonadotropin receptors and steroidogenic enzymes have been found to be expressed in neuroblasts in the hippocampus of the brain. However, the reciprocal relationship between hippocampal-specific neuroestradiol synthesis along neuroblastosis and response of pituitary based feedback regulation towards regulation of estradiol level in the hippocampus have not completely been ascertained. Therefore, this conceptual article revisits (1) the cellular basis of neuroestradiol synthesis (2) a potential relationship between neuroestradiol synthesis and neuroblastosis in the hippocampus (3) the possible involvement of aberrant neuroestradiol production with mitochondrial dysfunctions and dyslipidemia in menopause and adult-onset neurodegenerative disorders and (4) provides a hypothesis for the possible existence of the hypothalamic-pituitary-hippocampal (HPH) axis in the adult brain. Eventually, understanding the regulation of hippocampal neurogenesis by abnormal levels of neuroestradiol concentration in association with the feedback regulation of HPH axis might provide additional cues to establish a neuroregenerative therapeutic management for mood swings, depression and cognitive decline in menopause and neurocognitive disorders.</description><subject>17β-Estradiol</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Disorders</subject><subject>Dyslipidemia</subject><subject>Estradiol - biosynthesis</subject><subject>Estradiol - metabolism</subject><subject>Feedback</subject><subject>Female</subject><subject>Functional plasticity</subject><subject>Gonadotropins</subject><subject>Gonads</subject><subject>Hippocampal plasticity</subject><subject>Hippocampus</subject><subject>Hippocampus - physiology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Menopause</subject><subject>Menopause - physiology</subject><subject>Mental depression</subject><subject>Mitochondria</subject><subject>Mitochondrial Diseases - physiopathology</subject><subject>Mood</subject><subject>Nervous system</subject><subject>Neuroblasts</subject><subject>Neurochemistry</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Neurogenesis</subject><subject>Neurogenesis - physiology</subject><subject>Neurology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neuroplasticity</subject><subject>Neurosciences</subject><subject>Pituitary</subject><subject>Pituitary (anterior)</subject><subject>Pituitary Gland - physiology</subject><subject>Pituitary Gland - physiopathology</subject><subject>Receptors</subject><subject>Review</subject><subject>Sex hormones</subject><subject>Synthesis</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9Uktv1DAQjhCILoU_wAFZ4lIOAT-SOOG2LYUgFVhB75HjTHZdJXZqO5T98UhMN4UiDpxszfcYj-dLkueMvmaUyjeBMVpkKWVVSnkpRMoeJCuWS5EWFRUPkxUVCAtW0aPkSQhXlKKMs8fJkWA8z3hOV8nPjQvBtAOQ8x8mRLAaiOtJ3AGp95OLOzWo0eh0Y-JsovL7tDbT5LQaJzWQk3pTvyJrVL4la_IVtJk8YgNeBxWNs2FnJnIK8QbAkr-V3yYk90aTzzB7ByF61RmH9b3F3sEEomy3gO2gQnS3JWPJegvGbsmpV8YGcmPibrE69OzBHwaIjnwC6yY1B7j30W5rTTTfgbwzwfkOfHiaPOrVEODZ3XmcXL4_vzyr04svHz6erS9SLWQeU-Ci71VW6gIUL0TetW0pO8pl3tG21LLjtMpVUegsZ1xKAW2rOBWl0nlFeS6Ok5PFFn_nesZhm9EEDcOgLLg5NBxXUTAhGUXqy3-oV272Fh-HrKyUFe5NIosvLO1xfR76ZvJmxO00jDa32WiWbDSYjeaQjYah6MWd9dyO0P2R_A4DEsRCCAjZLfj73v-x_QVmJ8oO</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Kandasamy, Mahesh</creator><creator>Radhakrishnan, Risna Kanjirassery</creator><creator>Poornimai Abirami, G. 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P. ; Roshan, Syed Aasish ; Yesudhas, Ajisha ; Balamuthu, Kadalmani ; Prahalathan, Chidambaram ; Shanmugaapriya, Sellathamby ; Moorthy, Anbalagan ; Essa, Musthafa Mohamed ; Anusuyadevi, Muthuswamy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e23ffa48c6ea2635dbb87d0275d0b8c7d2095a66c4512773ebba2038ac590253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>17β-Estradiol</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Disorders</topic><topic>Dyslipidemia</topic><topic>Estradiol - biosynthesis</topic><topic>Estradiol - metabolism</topic><topic>Feedback</topic><topic>Female</topic><topic>Functional plasticity</topic><topic>Gonadotropins</topic><topic>Gonads</topic><topic>Hippocampal plasticity</topic><topic>Hippocampus</topic><topic>Hippocampus - physiology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Menopause</topic><topic>Menopause - physiology</topic><topic>Mental depression</topic><topic>Mitochondria</topic><topic>Mitochondrial Diseases - physiopathology</topic><topic>Mood</topic><topic>Nervous system</topic><topic>Neuroblasts</topic><topic>Neurochemistry</topic><topic>Neurodegenerative diseases</topic><topic>Neurodegenerative Diseases - physiopathology</topic><topic>Neurogenesis</topic><topic>Neurogenesis - physiology</topic><topic>Neurology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neuroplasticity</topic><topic>Neurosciences</topic><topic>Pituitary</topic><topic>Pituitary (anterior)</topic><topic>Pituitary Gland - physiology</topic><topic>Pituitary Gland - physiopathology</topic><topic>Receptors</topic><topic>Review</topic><topic>Sex hormones</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kandasamy, Mahesh</creatorcontrib><creatorcontrib>Radhakrishnan, Risna Kanjirassery</creatorcontrib><creatorcontrib>Poornimai Abirami, G. 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P.</au><au>Roshan, Syed Aasish</au><au>Yesudhas, Ajisha</au><au>Balamuthu, Kadalmani</au><au>Prahalathan, Chidambaram</au><au>Shanmugaapriya, Sellathamby</au><au>Moorthy, Anbalagan</au><au>Essa, Musthafa Mohamed</au><au>Anusuyadevi, Muthuswamy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Ageing Brains with Special Reference to Menopause and Neurocognitive Disorders</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>44</volume><issue>8</issue><spage>1781</spage><epage>1795</epage><pages>1781-1795</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocampal plasticity has been proposed to be regulated via neuroblasts, a major cellular determinant of functional neurogenesis in the adult brain. Defects in differentiation, integration and survival of neuroblasts in the hippocampus appear to be an underlying cause of neurocognitive disorders. Gonadotropin receptors and steroidogenic enzymes have been found to be expressed in neuroblasts in the hippocampus of the brain. However, the reciprocal relationship between hippocampal-specific neuroestradiol synthesis along neuroblastosis and response of pituitary based feedback regulation towards regulation of estradiol level in the hippocampus have not completely been ascertained. Therefore, this conceptual article revisits (1) the cellular basis of neuroestradiol synthesis (2) a potential relationship between neuroestradiol synthesis and neuroblastosis in the hippocampus (3) the possible involvement of aberrant neuroestradiol production with mitochondrial dysfunctions and dyslipidemia in menopause and adult-onset neurodegenerative disorders and (4) provides a hypothesis for the possible existence of the hypothalamic-pituitary-hippocampal (HPH) axis in the adult brain. Eventually, understanding the regulation of hippocampal neurogenesis by abnormal levels of neuroestradiol concentration in association with the feedback regulation of HPH axis might provide additional cues to establish a neuroregenerative therapeutic management for mood swings, depression and cognitive decline in menopause and neurocognitive disorders.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31254250</pmid><doi>10.1007/s11064-019-02833-1</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-6720-9082</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 2019-08, Vol.44 (8), p.1781-1795 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2250613710 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 17β-Estradiol Aging Aging - physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain Cell Biology Cognition Cognitive ability Disorders Dyslipidemia Estradiol - biosynthesis Estradiol - metabolism Feedback Female Functional plasticity Gonadotropins Gonads Hippocampal plasticity Hippocampus Hippocampus - physiology Hippocampus - physiopathology Humans Hypothalamus Menopause Menopause - physiology Mental depression Mitochondria Mitochondrial Diseases - physiopathology Mood Nervous system Neuroblasts Neurochemistry Neurodegenerative diseases Neurodegenerative Diseases - physiopathology Neurogenesis Neurogenesis - physiology Neurology Neuronal Plasticity - physiology Neuroplasticity Neurosciences Pituitary Pituitary (anterior) Pituitary Gland - physiology Pituitary Gland - physiopathology Receptors Review Sex hormones Synthesis |
| title | Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Ageing Brains with Special Reference to Menopause and Neurocognitive Disorders |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T21%3A00%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Possible%20Existence%20of%20the%20Hypothalamic-Pituitary-Hippocampal%20(HPH)%20Axis:%20A%20Reciprocal%20Relationship%20Between%20Hippocampal%20Specific%20Neuroestradiol%20Synthesis%20and%20Neuroblastosis%20in%20Ageing%20Brains%20with%20Special%20Reference%20to%20Menopause%20and%20Neurocognitive%20Disorders&rft.jtitle=Neurochemical%20research&rft.au=Kandasamy,%20Mahesh&rft.date=2019-08-01&rft.volume=44&rft.issue=8&rft.spage=1781&rft.epage=1795&rft.pages=1781-1795&rft.issn=0364-3190&rft.eissn=1573-6903&rft_id=info:doi/10.1007/s11064-019-02833-1&rft_dat=%3Cproquest_cross%3E2250613710%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2248795427&rft_id=info:pmid/31254250&rfr_iscdi=true |