Substrate-Based Allosteric Regulation of a Homodimeric Enzyme

Many enzymes operate through half-of-the sites reactivity wherein a single protomer is catalytically engaged at one time. In the case of the homodimeric enzyme, fluoroacetate dehalogenase, substrate binding triggers closing of a regulatory cap domain in the empty protomer, preventing substrate acces...

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Veröffentlicht in:	Journal of the American Chemical Society 2019-07, Vol.141 (29), p.11540-11556
Hauptverfasser:	Mehrabi, Pedram, Di Pietrantonio, Christopher, Kim, Tae Hun, Sljoka, Adnan, Taverner, Keith, Ing, Christopher, Kruglyak, Natasha, Pomès, Régis, Pai, Emil F, Prosser, R. Scott
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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