5-Hydrazinylethylidenepyrimidines effective against multidrug-resistant Acinetobacter baumannii: Synthesis and in vitro biological evaluation of antibacterial, radical scavenging and cytotoxic activities

Acinetobacter baumannii has emerged as an important nosocomial pathogen in recent years, with infectious outbreaks caused by multidrug-resistant strains increasing worldwide. Thus, new antibacterial treatments for multidrug-resistant A. baumannii strains are needed. In this work, a series of 5-hydra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmaceutical sciences 2019-09, Vol.137, p.104964-104964, Article 104964
Hauptverfasser:	Figueiredo, Joana, Serrano, João L., Soares, Mafalda, Ferreira, Susana, Domingues, Fernanda C., Almeida, Paulo, Silvestre, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydrazinylethylidenepyrimidines Acinetobacter baumannii - drug effects Acinetobacter baumannii - growth & development Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - toxicity Antibacterial effects Antioxidant activity Biphenyl Compounds - chemistry Cell Line Cell Survival - drug effects Computer Simulation Cytotoxicity Drug Resistance, Multiple, Bacterial - drug effects Escherichia coli - drug effects Escherichia coli - growth & development Fibroblasts - drug effects Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacokinetics Free Radical Scavengers - pharmacology Free Radical Scavengers - toxicity Humans Microbial Sensitivity Tests Models, Biological Multidrug-resistant A. baumannii Picrates - chemistry Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development Pyrimidines - chemistry Pyrimidines - pharmacokinetics Pyrimidines - pharmacology Pyrimidines - toxicity Xanthine Oxidase - chemistry Xanthine oxidase inhibition
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!