Detection of Insulin-Like Growth Factor 1 Variants by Mass Spectrometry: Results from a Clinical Reference Laboratory

To the Editor: In 2011, Bystrom et al. developed a top-down liquid chromatography- high-resolution mass spectrometry (LC-HRMS)1 assay for insulin-like growth factor 1 (IGF-1) quantification (1). Because V44M and R36Qreduce IGF-1 binding affinity to its receptor by 86 and 3.9-fold, respectively (4),...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2019-08, Vol.65 (8), p.1060-1061
Hauptverfasser:	Wu, Zengru, Sanders, Heather, Motorykin, Ievgen, Phillip Caulfield, Michael, John McPhaul, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine Binding Chromatography Deoxyribonucleic acid DNA DNA - analysis DNA - chemistry Growth factors High resolution Humans Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-like growth factors Liquid chromatography Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Mutation Nucleotides Polymorphism Polymorphism, Single Nucleotide - genetics Scientific imaging Sequence Analysis, DNA Single-nucleotide polymorphism Spectroscopy Valine
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