Novel adenoviral IGF-1 administration modulates the association between depressive symptoms and aging: Does gender matter?

•Frailty phenotype underlies depressive-like symptoms in aged mice model.•Behavior linked to depression is influenced by age and gender.•IGF-1 is capable to modulate depressive-like phenotype in aged mice.•IGF-1 intramuscular gene therapy is a feasible therapeutic approach to ameliorate aged associa...

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Veröffentlicht in:	Behavioural brain research 2019-10, Vol.372, p.112050-112050, Article 112050
Hauptverfasser:	Herrera, Macarena Lorena, Basmadjian, Osvaldo Martín, Falomir Lockhart, Eugenia, Dolcetti, Franco Juan-Cruz, Hereñú, Claudia Beatriz, Bellini, María José
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Depressive symptoms Frailty IGF-1 Sexual dimorphism
Online-Zugang:	Volltext
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