Survival of glioblastoma cells in response to endogenous and exogenous oxidative challenges: possible implication of NMDA receptor‐mediated regulation of redox homeostasis

Cancer cells are highly metabolically active and produce high levels of reactive oxygen species (ROS). Drug resistance in cancer cells is closely related to their redox status. The role of ROS and its impact on cancer cell survival seems far from elucidation. The mechanisms through which glioblastom...

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Veröffentlicht in:	Cell biology international 2019-12, Vol.43 (12), p.1443-1452
Hauptverfasser:	Dalavaikodihalli Nanjaiah, Nandakumar, Ramaswamy, Palaniswamy, Goswami, Kalyan, Fathima K, Hurmath, Borkotokey, Monjuri
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant Antioxidants Brain cancer Cancer Catalase Cell survival Cell viability Chemoresistance Drug resistance Glioblastoma Glioblastoma cells Glioma cells glutamate receptor Glutamic acid receptors (ionotropic) glutathione redox cycle Glutathione reductase Homeostasis Hydrogen peroxide Intracellular N-Methyl-D-aspartic acid receptors Oxidative stress Reactive oxygen species
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