ALDH1A1 in patient‐derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression

Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long‐term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor‐initiating potential, or cancer stem‐like cells (CSCs), may particularly contribute to acquired chemoresistance and r...

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Veröffentlicht in:	International journal of cancer 2020-02, Vol.146 (4), p.1099-1113
Hauptverfasser:	Namekawa, Takeshi, Ikeda, Kazuhiro, Horie‐Inoue, Kuniko, Suzuki, Takashi, Okamoto, Koji, Ichikawa, Tomohiko, Yano, Akihiro, Kawakami, Satoru, Inoue, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde dehydrogenase Aldehyde Dehydrogenase 1 - antagonists & inhibitors Aldehyde Dehydrogenase 1 - genetics Aldehyde Dehydrogenase 1 - metabolism ALDH1A1 Animals Bladder cancer Cancer cancer stem‐like cells Cell culture Cell Line, Tumor Chemoresistance Disease Progression Down-Regulation HEK293 Cells Heterografts Humans Male Medical prognosis Medical research Mice Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Patients patient‐derived cells Regulatory sequences Retinal Dehydrogenase - antagonists & inhibitors Retinal Dehydrogenase - genetics Retinal Dehydrogenase - metabolism Retinoic acid Retinoic Acid Receptor alpha Signal Transduction spheroid Spheroids Spheroids, Cellular Transcription Tretinoin TUBB3 Tubulin Tubulin - biosynthesis Tubulin - genetics Tumor cells Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Xenografts
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