RGD-containing elastin-like polypeptide improves islet transplantation outcomes in diabetic mice

[Display omitted] Successful islet transplantation critically depends on the isolation of healthy islets. However, the islet isolation procedure itself contributes to islet death due to the destruction of intra- and peri-islet extracellular matrices (ECMs) during digestion. We investigated whether a...

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Veröffentlicht in:	Acta biomaterialia 2019-08, Vol.94, p.351-360
Hauptverfasser:	Lee, Kyeong-Min, Kim, Jung-Hee, Choi, Eun-Sook, Kim, Eunjoo, Choi, Seong-Kyoon, Jeon, Won Bae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Cell culture Cell death Cell Line Cell Proliferation Cell Survival Coacervation Diabetes Diabetes mellitus Diabetes Mellitus, Experimental Elastin Elastin - chemistry Gelation Gene Expression Regulation Insulin Insulin - metabolism Insulin secretion Insulin Secretion - drug effects Islet cells Islet survival Islet transplantation Islets of Langerhans - cytology Islets of Langerhans Transplantation - methods Male Mice Mice, Inbred C57BL Oligopeptides - chemistry Oligopeptides - metabolism Pancreatic islet transplantation Polypeptides Protein coacervate Rats, Sprague-Dawley RGD-containing elastin-like polypeptide RNA, Messenger - metabolism Signal Transduction Streptozocin Thermal gelation Transplantation Transplants Transplants & implants Treatment Outcome Vascularization Viability
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