Alcohol-induced conditioned place preference is modulated by CB2 cannabinoid receptors and modifies levels of endocannabinoids in the mesocorticolimbic system

The endocannabinoid (eCB) system is a particularly important neuronal mechanism implicated in alcohol use disorders. Animal models are key to broadening our knowledge of the neurobiological mechanisms underlying alcohol dependence. This study has two main aims: i) to assess how eCB levels in differe...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2019-08, Vol.183, p.22-31
Hauptverfasser:	Martín-Sánchez, Ana, Warnault, Vincent, Montagud-Romero, Sandra, Pastor, Antoni, Mondragón, Neus, De La Torre, Rafael, Valverde, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Animals Arachidonic Acids - metabolism Behavior, Animal - drug effects Cannabinoid Receptor Agonists - pharmacology Cannabinoid Receptor Antagonists - pharmacology Cannabinoids - pharmacology CB2R cannabinoid receptors Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - pharmacology Conditioned place preference Conditioning, Classical - drug effects Dopaminergic Neurons - metabolism Endocannabinoids Endocannabinoids - metabolism Ethanol - administration & dosage Ethanol - pharmacology Indoles - pharmacology Locomotion - drug effects Male Mesencephalon - metabolism Mice Mice, Inbred C57BL Polyunsaturated Alkamides - metabolism Prefrontal Cortex - metabolism Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - metabolism Reward
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