MeCP2: an epigenetic regulator of critical periods
•MeCP2 regulates the timing of critical periods in sensory cortex.•MeCP2 binds and drives expression of genes implicated in synaptic plasticity and the expression of CP.•MeCP2 controls CP in a cell-specific manner. Complex adult behaviors arise from the integration of sequential and often overlappin...
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| Veröffentlicht in: | Current opinion in neurobiology 2019-12, Vol.59, p.95-101 |
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| container_title | Current opinion in neurobiology |
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| creator | Picard, Nathalie Fagiolini, Michela |
| description | •MeCP2 regulates the timing of critical periods in sensory cortex.•MeCP2 binds and drives expression of genes implicated in synaptic plasticity and the expression of CP.•MeCP2 controls CP in a cell-specific manner.
Complex adult behaviors arise from the integration of sequential and often overlapping critical periods (CPs) early in life and adolescence. These processes rely on a subtle interplay between the set of genes inherited from the parents, the surrounding environment and epigenetic regulation. Methyl-CpG-binding protein 2 (MeCP2) has been shown to recognize epigenetic states and regulate gene expression by reading methylated DNA. Here, we will review the recent findings revealing the role of MeCP2 during postnatal CPs of development using mouse models of Rett (RTT) syndrome. |
| doi_str_mv | 10.1016/j.conb.2019.04.004 |
| format | Article |
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Complex adult behaviors arise from the integration of sequential and often overlapping critical periods (CPs) early in life and adolescence. These processes rely on a subtle interplay between the set of genes inherited from the parents, the surrounding environment and epigenetic regulation. Methyl-CpG-binding protein 2 (MeCP2) has been shown to recognize epigenetic states and regulate gene expression by reading methylated DNA. Here, we will review the recent findings revealing the role of MeCP2 during postnatal CPs of development using mouse models of Rett (RTT) syndrome.</description><identifier>ISSN: 0959-4388</identifier><identifier>EISSN: 1873-6882</identifier><identifier>DOI: 10.1016/j.conb.2019.04.004</identifier><identifier>PMID: 31163286</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Epigenesis, Genetic ; Humans ; Methyl-CpG-Binding Protein 2 ; Mice ; Rett Syndrome</subject><ispartof>Current opinion in neurobiology, 2019-12, Vol.59, p.95-101</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-feeb4b3c20ce323d070ff18fa2ca522ca29c61f41414dffa2741751464e571dc3</citedby><cites>FETCH-LOGICAL-c356t-feeb4b3c20ce323d070ff18fa2ca522ca29c61f41414dffa2741751464e571dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.conb.2019.04.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31163286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Picard, Nathalie</creatorcontrib><creatorcontrib>Fagiolini, Michela</creatorcontrib><title>MeCP2: an epigenetic regulator of critical periods</title><title>Current opinion in neurobiology</title><addtitle>Curr Opin Neurobiol</addtitle><description>•MeCP2 regulates the timing of critical periods in sensory cortex.•MeCP2 binds and drives expression of genes implicated in synaptic plasticity and the expression of CP.•MeCP2 controls CP in a cell-specific manner.
Complex adult behaviors arise from the integration of sequential and often overlapping critical periods (CPs) early in life and adolescence. These processes rely on a subtle interplay between the set of genes inherited from the parents, the surrounding environment and epigenetic regulation. Methyl-CpG-binding protein 2 (MeCP2) has been shown to recognize epigenetic states and regulate gene expression by reading methylated DNA. Here, we will review the recent findings revealing the role of MeCP2 during postnatal CPs of development using mouse models of Rett (RTT) syndrome.</description><subject>Animals</subject><subject>Epigenesis, Genetic</subject><subject>Humans</subject><subject>Methyl-CpG-Binding Protein 2</subject><subject>Mice</subject><subject>Rett Syndrome</subject><issn>0959-4388</issn><issn>1873-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOo7-ARfSpZvWvJqm4kYGXzCiC12HNL0ZMnSamrSC_94MM7qUC_fC4ZwD90PoguCCYCKu14XxfVNQTOoC8wJjfoBmRFYsF1LSQzTDdVnnnEl5gk5jXGOMBZPsGJ0wQgSjUswQfYHFG73JdJ_B4FbQw-hMFmA1dXr0IfM2M8ElTXfZAMH5Np6hI6u7COf7O0cfD_fvi6d8-fr4vLhb5oaVYswtQMMbZig2wChrcYWtJdJqanRJ06K1EcRykqa1Sa44qUrCBYeyIq1hc3S16x2C_5wgjmrjooGu0z34KSpKeSm4KCVJVrqzmuBjDGDVENxGh29FsNqyUmu1ZaW2rBTmKrFKoct9_9RsoP2L_MJJhtudAdKXXw6CisZBb6B1AcyoWu_-6_8Bg2l5Hg</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Picard, Nathalie</creator><creator>Fagiolini, Michela</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201912</creationdate><title>MeCP2: an epigenetic regulator of critical periods</title><author>Picard, Nathalie ; Fagiolini, Michela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-feeb4b3c20ce323d070ff18fa2ca522ca29c61f41414dffa2741751464e571dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Epigenesis, Genetic</topic><topic>Humans</topic><topic>Methyl-CpG-Binding Protein 2</topic><topic>Mice</topic><topic>Rett Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Picard, Nathalie</creatorcontrib><creatorcontrib>Fagiolini, Michela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Picard, Nathalie</au><au>Fagiolini, Michela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MeCP2: an epigenetic regulator of critical periods</atitle><jtitle>Current opinion in neurobiology</jtitle><addtitle>Curr Opin Neurobiol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>59</volume><spage>95</spage><epage>101</epage><pages>95-101</pages><issn>0959-4388</issn><eissn>1873-6882</eissn><abstract>•MeCP2 regulates the timing of critical periods in sensory cortex.•MeCP2 binds and drives expression of genes implicated in synaptic plasticity and the expression of CP.•MeCP2 controls CP in a cell-specific manner.
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| ispartof | Current opinion in neurobiology, 2019-12, Vol.59, p.95-101 |
| issn | 0959-4388 1873-6882 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Epigenesis, Genetic Humans Methyl-CpG-Binding Protein 2 Mice Rett Syndrome |
| title | MeCP2: an epigenetic regulator of critical periods |
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