A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain
Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activ...
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| Veröffentlicht in: | Archives of virology 2019-09, Vol.164 (9), p.2355-2358 |
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| container_title | Archives of virology |
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| creator | Nemoto, Manabu Yamayoshi, Seiya Bannai, Hiroshi Tsujimura, Koji Kokado, Hiroshi Kawaoka, Yoshihiro Yamanaka, Takashi |
| description | Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activity of antiserum against a former vaccine strain. To confirm this suggestion, here, we generated viruses by reverse genetics. Antibody titers against the mutated viruses were one-tenth to one-sixteenth of those against the former vaccine strain. Our findings confirm that this single amino acid substitution reduces the cross-reactivity of antiserum against this former Japanese vaccine. |
| doi_str_mv | 10.1007/s00705-019-04328-4 |
| format | Article |
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Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activity of antiserum against a former vaccine strain. To confirm this suggestion, here, we generated viruses by reverse genetics. Antibody titers against the mutated viruses were one-tenth to one-sixteenth of those against the former vaccine strain. Our findings confirm that this single amino acid substitution reduces the cross-reactivity of antiserum against this former Japanese vaccine.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-019-04328-4</identifier><identifier>PMID: 31227892</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Amino acid substitution ; Antisera ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; Cross-reactivity ; Hemagglutinins ; Infectious Diseases ; Influenza ; Medical Microbiology ; Vaccination ; Vaccines ; Virology ; Viruses</subject><ispartof>Archives of virology, 2019-09, Vol.164 (9), p.2355-2358</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2019</rights><rights>Archives of Virology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e38057e4a6b6b60c29e07863f39d5109bd38c529f139d6d313069a7db926e2873</citedby><cites>FETCH-LOGICAL-c441t-e38057e4a6b6b60c29e07863f39d5109bd38c529f139d6d313069a7db926e2873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-019-04328-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-019-04328-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31227892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nemoto, Manabu</creatorcontrib><creatorcontrib>Yamayoshi, Seiya</creatorcontrib><creatorcontrib>Bannai, Hiroshi</creatorcontrib><creatorcontrib>Tsujimura, Koji</creatorcontrib><creatorcontrib>Kokado, Hiroshi</creatorcontrib><creatorcontrib>Kawaoka, Yoshihiro</creatorcontrib><creatorcontrib>Yamanaka, Takashi</creatorcontrib><title>A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. 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| subjects | Amino acid substitution Antisera Biomedical and Life Sciences Biomedicine Brief Report Cross-reactivity Hemagglutinins Infectious Diseases Influenza Medical Microbiology Vaccination Vaccines Virology Viruses |
| title | A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain |
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